Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2025-02-01 DOI:10.1080/10426507.2025.2461042

Ekaterina Mikhailovna Arzyamova , Alevtina Yur’evna Yegorova

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Abstract

A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (¹H,¹³C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (E)-5-aryl-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-ones exist only in the E-configuration. Their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was studied in liquid nutrient media by the serial dilution method. The results showed that (E)-5-(4-chlorophenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one and (E)-5-(4-methoxyphenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one demonstrated the best in vitro antibacterial properties against the bacterial culture Escherichia coli.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.