Equilibrium Solubility, Thermodynamic Correlation, and Solvent Effects of Metamifop Form A in Pure Solvents and Binary Mixture Solvents

Abstract

The solubility of Metamifop Form A was determined gravimetrically in nine pure solvents (including two antisolvents) and three binary mixture solvents in the temperature ranges of 278.15–303.15 and 278.15–313.15 K, respectively. A good correlation was established between the experimentally measured solubility data and data correlation models (including the λh model, modified Apelblat model, Yaws model, and Apelblat–Jouyban–Acree model). The KAT-LSER model was used to fit the experimental data of Metamifop Form A in pure solvents at room temperature to analyze the solvent effect. Finally, Hirshfeld surface analysis (HS) and molecular electrostatic potential surfaces (MEPS) were employed to visualize intermolecular interactions and the charge distribution of Metamifop Form A.