Solubility Measurements of Finerenone in Ten Monosolvents and Two Binary Solvent Mixtures

Abstract

The solubility of finerenone, a third-generation nonsteroidal mineralocorticoid receptor antagonist drug, was measured in 10 monosolvents (methanol, ethanol, isopropanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, acetonitrile, and dichloromethane) and two binary solvent mixtures (methanol + water and acetonitrile + water). Measurements were conducted at temperatures ranging from 273.15 to 313.15 K using PAT tools. In the methanol + water system, water acted solely as an antisolvent. However, in the acetonitrile + water system, finerenone’s solubility exceeded its solubility in pure acetonitrile, reaching a maximum at a water mass fraction of approximately 0.2. To expand the applicability of the results, the experimental solubility data was correlated with the modified Apelblat model, the λh model, and the CNIBS/R-K model. The relative average deviation and root-mean-square deviation values indicate that the correlation results align well with the experimental data, and the modified Apelblat model proved the most suitable.