Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-03-12 DOI:10.1038/s41594-025-01499-4

引用次数: 0

Abstract

Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain. Cryo-electron microscopy of tau filaments from individuals with mutant V337M and R406W tau show the Alzheimer fold.

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来自某些遗传性额颞叶痴呆的突变tau纤维显示阿尔茨海默氏褶皱

额颞叶痴呆可能是由编码tau蛋白的MAPT突变引起的；突变蛋白在大脑中形成有害的聚集体。来自突变型V337M和R406W tau个体的tau细丝的冷冻电镜显示阿尔茨海默氏褶皱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.