It takes three: A cocktail of protists, bacterial sphingolipids and an inflammasome

IF 18.7 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-03-12 DOI:10.1016/j.chom.2025.02.013

Michael E. Grigg, Eliza V.C. Alves-Ferreira

引用次数: 0

Abstract

Symbiotic relationships between mammalian hosts and their flora impact host immunity and disease. In this issue, Winsor and colleagues define a trans-kingdom interaction, which protects against colorectal cancer. Tritrichomonas protists initiate a Bacteroides bloom and sphingolipid release, which activates the NLRP6 inflammasome, enhancing protective mucus secretion by sentinel goblet cells.

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它需要三种物质：原生生物、细菌鞘脂和炎性体的混合物

哺乳动物宿主及其菌群之间的共生关系影响宿主的免疫和疾病。在这期杂志中，Winsor和他的同事们定义了一种跨王国的相互作用，它可以预防结直肠癌。原生三毛单胞菌引发拟杆菌爆发和鞘脂释放，激活NLRP6炎性体，增强哨兵杯状细胞的保护性粘液分泌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.