Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-03-10 DOI:10.1021/acs.oprd.4c00535

Ruchi Chauhan, Abhilash Rana, Amirreza Mottafegh, Dong Pyo Kim, Ajay K. Singh

引用次数: 0

Abstract

A novel approach has been utilized in a continuous flow auto-optimizer for multistep apixaban (APX) synthesis, cutting residence time to 17.2 min and boosting overall yield by 78%. This AI-driven tool bypasses traditional trial-and-error methods, streamlining reactivity space navigation and enhancing productivity. It is designed to reduce APX production costs, improve space-time yield, and facilitate the transition from batch to continuous manufacturing, addressing critical gaps in the industry and advancing the field of digital smart workflows.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.