Impact of technical, patient-related and measurement variables on serial Hounsfield unit-based quantitative coronary plaque analysis in computed tomography: time for a new chapter.

European heart journal. Imaging methods and practice Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI:10.1093/ehjimp/qyaf014

Francesca Calicchio, Elizabeth Epstein, Melinda Boussoussou, Borbála Vattay, Alexander van Rosendael, Shawn Newlander, Márton Kolossváry, Bálint Szilveszter, Pál Maurovich-Horvat, Hugo Marques, Elliot McVeigh, George Wesbey

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Abstract

This review article explores the challenges and controversies involved in accurately identifying and reliably quantifying coronary plaque over time through coronary computed tomography angiography (CCTA), particularly focusing on lipid-rich, low-attenuation plaques. It highlights significant variability in lipid-rich plaque measurements across studies, questioning their reliability for tracking biological plaque transformation in clinical practice. To address this issue, the review article proposes suggestions for serial CCTA plaque measurements, aiming for realistic goals for reproducible and meaningful serial plaque CCTA imaging. It also emphasizes the necessity of standardized, validated methods for quantitative plaque analysis and underscores the potential of phantom-based calibration to improve the reliability and consistency of serial plaque measurements in clinical practice.

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技术、患者相关和测量变量对计算机断层扫描中基于Hounsfield单位的冠状动脉斑块定量分析的影响：是时候翻开新的一章了。

这篇综述文章探讨了通过冠状动脉计算机断层血管造影（CCTA）准确识别和可靠量化冠状动脉斑块的挑战和争议，特别是关注富含脂质、低衰减的斑块。它强调了研究中富脂斑块测量的显著差异，质疑其在临床实践中跟踪生物斑块转化的可靠性。为了解决这个问题，综述文章提出了连续CCTA斑块测量的建议，旨在实现可重复和有意义的连续斑块CCTA成像的现实目标。它还强调了标准化的、经过验证的定量斑块分析方法的必要性，并强调了基于幽灵的校准在临床实践中提高系列斑块测量的可靠性和一致性的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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European heart journal. Imaging methods and practice

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