Noncontact Detection of Blood Coagulation Dynamics Based on Speckle Deviation Analysis Using Optical Coherence Tomography

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2025-03-11 DOI:10.1002/jbio.70002

Yun Tang, Zongqing Ma, Yuxian Zhang, Fan Fan, Fan Zhang, Jiang Zhu

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Abstract

Red blood cells aggregate from individual cells into larger aggregates during blood coagulation. This process causes the light-scattering particles to enlarge and their motion to become restricted. The size and motion of these light-scattering particles during coagulation provide valuable information on the progress of blood coagulation. This paper proposes an optical coherence tomography speckle deviation (OCT-SD) method for the noncontact assessment of blood coagulation dynamics by detecting changes in the size and motion of scattering particles. The coagulation characteristics of static and flowing blood were quantitatively evaluated through coagulation reaction time and clot formation duration by monitoring the blood coagulation process. The OCT imaging, incorporating SD analysis, enables noncontact coagulation assessment. Experimental results demonstrate that the proposed method can efficiently and accurately assess coagulation dynamics, offering significant potential for in situ coagulation detection.

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基于光学相干断层成像散斑偏差分析的非接触血液凝固动力学检测。

在血液凝固过程中，红细胞从单个细胞聚集成更大的聚集体。这个过程导致光散射粒子扩大，它们的运动受到限制。凝血过程中这些光散射粒子的大小和运动为血液凝固过程提供了有价值的信息。本文提出了一种光学相干断层扫描散斑偏差（OCT-SD）方法，通过检测散射粒子的大小和运动变化来非接触评估血液凝固动力学。通过监测血液凝固过程，通过凝血反应时间和凝块形成时间，定量评价静、流动血液的凝血特性。OCT成像，结合SD分析，实现非接触凝血评估。实验结果表明，该方法可以有效、准确地评估凝血动力学，为原位凝血检测提供了巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.