{"title":"Roles of methyl-CpG-binding-domain (MBD) protiens in regulation of biological processes in plants.","authors":"Sanskriti Ravi, Amrapali Sharma, Arun Kumar Sharma","doi":"10.1007/s12298-025-01556-8","DOIUrl":null,"url":null,"abstract":"<p><p>DNA methylation is a key epigenetic mark found in both eukaryotic as well as prokaryotic genomes. It is essential for regulating expression of genes and preservation of genomic integrity. Both plants and animals possess specific proteins that mediate biological effects of DNA methylation. Many families of such methylated DNA binding proteins have been discovered in plants; the most prominent of them being the methyl-CpG- binding domain (MBD) proteins. Some of the MBD proteins have the ability to recognize methylated CpGs in vitro and in vivo. In this review, we have described MBD proteins and their functions in a wide range of cellular processes in various plant species. We have also outlined their mechanism of action and interacting protein partners.</p>","PeriodicalId":20148,"journal":{"name":"Physiology and Molecular Biology of Plants","volume":"31 2","pages":"163-171"},"PeriodicalIF":3.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890390/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiology and Molecular Biology of Plants","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12298-025-01556-8","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
DNA methylation is a key epigenetic mark found in both eukaryotic as well as prokaryotic genomes. It is essential for regulating expression of genes and preservation of genomic integrity. Both plants and animals possess specific proteins that mediate biological effects of DNA methylation. Many families of such methylated DNA binding proteins have been discovered in plants; the most prominent of them being the methyl-CpG- binding domain (MBD) proteins. Some of the MBD proteins have the ability to recognize methylated CpGs in vitro and in vivo. In this review, we have described MBD proteins and their functions in a wide range of cellular processes in various plant species. We have also outlined their mechanism of action and interacting protein partners.
期刊介绍：
Founded in 1995, Physiology and Molecular Biology of Plants (PMBP) is a peer reviewed monthly journal co-published by Springer Nature. It contains research and review articles, short communications, commentaries, book reviews etc., in all areas of functional plant biology including, but not limited to plant physiology, biochemistry, molecular genetics, molecular pathology, biophysics, cell and molecular biology, genetics, genomics and bioinformatics. Its integrated and interdisciplinary approach reflects the global growth trajectories in functional plant biology, attracting authors/editors/reviewers from over 98 countries.
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