Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the treatment and control of Echinococcus multilocularis and E. granulosus infections in dogs.
Samuel Charles, Gertraut Altreuther, Xinshuo Wang, Scott Wiseman, Craig R Reinemeyer, Daniel E Snyder, Michael Ulrich, Padraig Doherty, Lisa Young
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引用次数: 0
Abstract
Background: While generally harmless to dogs, the cestode species Echinococcus granulosus and Echinococcus multilocularis have significant zoonotic importance, causing cystic echinococcosis and alveolar echinococcosis in humans, respectively. Regular deworming is essential to treat intestinal cestode infections in dogs and to reduce environmental egg contamination and thus the subsequent zoonotic risk of infection to intermediate hosts and humans. The studies described here evaluated the efficacy of a new novel chewable tablet combination containing lotilaner, moxidectin, praziquantel and pyrantel (Credelio Quattro, Elanco Animal Health) against E. granulosus and E. multilocularis infections in dogs.
Methods: Four negative-controlled, masked, randomized laboratory studies were conducted. Two studies each evaluated the efficacy of Credelio Quattro at the minimum dosages of 20.0 mg/kg lotilaner, 0.02 mg/kg moxidectin, 5.0 mg/kg praziquantel and 5.0 mg/kg pyrantel against E. granulosus (Studies 1 and 2) and E. multilocularis (Studies 3 and 4). Studies 2 and 4 also included treatment groups that received praziquantel alone or lotilaner alone, at the same minimum dosages, to assess whether lotilaner, moxidectin or pyrantel interfered with the activity of praziquantel in Credelio Quattro against these two cestode species. In Studies 1 and 3, 16 purpose-bred dogs were divided into two groups of eight, while in Studies 2 and 4, 32 dogs were divided into four groups of eight. Dogs were experimentally inoculated with protoscolices on Day - 28 for E. granulosus studies and on Day - 18 or - 20 for E. multilocularis studies. Credelio Quattro, placebo, praziquantel, or lotilaner tablets were administered orally at the lower half of the dosage range on Day 0. Efficacy was calculated based on the number of worms recovered at necropsy, 4 or 5 days post-treatment, in the treated group compared to the control.
Results: Credelio Quattro was well tolerated in all dogs. Based on geometric mean worm counts, Credelio Quattro was 100% effective against both E. granulosus and E. multilocularis.
Conclusions: Credelio Quattro administered once orally at the minimum dosages of 20 mg/kg of lotilaner, 0.02 mg/kg of moxidectin, 5.0 mg/kg of praziquantel and 5.0 mg/kg of pyrantel was safe and effective for the treatment and control of adult E. granulosus and E. multilocularis in dogs.
期刊介绍:
Parasites & Vectors is an open access, peer-reviewed online journal dealing with the biology of parasites, parasitic diseases, intermediate hosts, vectors and vector-borne pathogens. Manuscripts published in this journal will be available to all worldwide, with no barriers to access, immediately following acceptance. However, authors retain the copyright of their material and may use it, or distribute it, as they wish.
Manuscripts on all aspects of the basic and applied biology of parasites, intermediate hosts, vectors and vector-borne pathogens will be considered. In addition to the traditional and well-established areas of science in these fields, we also aim to provide a vehicle for publication of the rapidly developing resources and technology in parasite, intermediate host and vector genomics and their impacts on biological research. We are able to publish large datasets and extensive results, frequently associated with genomic and post-genomic technologies, which are not readily accommodated in traditional journals. Manuscripts addressing broader issues, for example economics, social sciences and global climate change in relation to parasites, vectors and disease control, are also welcomed.