Effects of Vitamin Administration on Orthodontic Tooth Movement: A Scoping Review.

Abstract

Context: Orthodontic tooth movement (OTM) is possible by bone remodeling that takes place during orthodontic therapy. The rate at which teeth move is determined by a variety of factors that can impact bone remodeling. Vitamins are well-known antioxidants that influence bone turnover.

Objective: This scoping review was designed to appraise the effects of the local and systemic administration of vitamins C, D, and E principally on fixed orthodontic treatment, retention, and relapse.

Method: A scoping review protocol was applied following the recommendations of the Preferred Reporting Item for Systematic Reviews and Meta-analysis Guidelines for Scoping Reviews. A detailed search strategy, including main keywords and synonyms, was applied in the following electronic databases: PubMed (via MEDLINE), Embase (via Ovid), Cochrane Library, and Web of Sciences, for articles published in English in the past 10 years.

Results: The database online search identified 70 potential articles. After removing duplicates, 39 full-text articles were independently evaluated. Eighteen studies were discarded. The remaining 21 studies were finally included. Of these selected studies, 8 were conducted on animals, 9 were conducted with human participants, 1 was an in vitro study, and 3 were systematic reviews. One systematic review and meta-analysis was also included.

Conclusion: Based on a variety of animal and human investigations, the findings of this scoping review imply that vitamins C, D, and E accelerate OTM by facilitating the bone remodeling process. However, more powerful randomized clinical trials are still required to reinforce the knowledge of vitamins' influence on orthodontic therapy.

Scoping review registration: OSF identifier 10.17605/OSF.IO/HNW9Z.