Automated fibrosis segmentation from wideband post-contrast T 1 ∗ $$ {T}_1^{\ast } $$ mapping in an animal model of ischemic heart disease with implantable cardioverter-defibrillators

IF 3 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Calder D. Sheagren, Terenz Escartin, Jaykumar H. Patel, Jennifer Barry, Graham A. Wright
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引用次数: 0

Abstract

Purpose

Post-contrast T 1 $$ {T}_1^{\ast } $$ mapping has proven promising for automated scar segmentation in subjects without ICDs, but this has not been implemented in patients with ICDs. We introduce an automated cluster-based thresholding method for T 1 $$ {T}_1^{\ast } $$ maps with an ICD present and compare it to manually tuned thresholding of synthetic LGE images with an ICD present and standard LGE without an ICD present.

Methods

Seven swine received an ischemia-reperfusion myocardial infarction and were imaged at 3 T 4–5 weeks post-infarct with and without an ICD. Mapping-based thresholding was performed using synthetic LGE and artifact-corrected cluster-thresholding methods, both employing connected component filtering. Standard pixel signal intensity thresholding was performed on the conventional LGE without an ICD. Volumetric accuracy is relative to conventional LGE and Dice similarity between SynLGE and cluster-based segmentations were evaluated.

Results

No statistical significance was observed between LGE volumes without an ICD and both SynLGE and artifact-corrected cluster-threshold volumes with an ICD, when using connected component filtering. Additionally, Dice alignment between SynLGE and cluster-thresholding was high for healthy myocardium (0.96), dense scar (0.83), and dense scar union gray zone (0.91) when artifact correction and connected component filtering were implemented.

Conclusion

Clustering of T 1 $$ {T}_1^{\ast } $$ maps holds promise for a reproducible approach to scar segmentation in the presence of ICDs.

Abstract Image

在植入式心律转复除颤器的缺血性心脏病动物模型中,从宽带对比后t1 * $$ {T}_1^{\ast } $$映射自动纤维化分割。
目的:对比后t1 * $$ {T}_1^{\ast } $$映射已被证明有希望在没有icd的受试者中自动分割疤痕,但这尚未在icd患者中实施。我们引入了一种自动的基于聚类的阈值方法,用于t1∗$$ {T}_1^{\ast } $$具有ICD的地图,并将其与人工调整的具有ICD的合成LGE图像和没有ICD的标准LGE图像的阈值进行比较。方法:7头猪接受缺血再灌注心肌梗死,并在梗死后3 T - 4周,在有和没有ICD的情况下进行成像。基于映射的阈值处理采用综合LGE和伪影校正聚类阈值处理方法,两者均采用连通分量滤波。在没有ICD的常规LGE上进行标准像素信号强度阈值处理。体积精度相对于传统的LGE和骰子相似度之间的SynLGE和基于聚类的分割进行了评估。结果:当使用连接分量过滤时,未使用ICD的LGE卷与使用ICD的SynLGE和伪影校正聚类阈值卷之间没有统计学意义。此外,当执行伪影校正和连接分量滤波时,SynLGE和聚类阈值之间的Dice对齐在健康心肌(0.96),密集疤痕(0.83)和密集疤痕联合灰色区域(0.91)中都很高。结论:t1 * $$ {T}_1^{\ast } $$图谱的聚类有望在icd存在的情况下再现疤痕分割的方法。
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来源期刊
CiteScore
6.70
自引率
24.20%
发文量
376
审稿时长
2-4 weeks
期刊介绍: Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.
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