[The current role of isavuconazole in the treatment of invasive fungal infections].

Q3 Medicine
Ondrej Zahornacky, Pavol Jarčuška
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引用次数: 0

Abstract

Significant medical advances in the treatment and management of immunocompromised patients are currently leading to an ever-increasing incidence of invasive fungal infections (IFI). Due to the limited antifungal treatment options, the management of IFI remains a major challenge. The triazole antifungal drug isavuconazole (ISV) shows a broader spectrum of activity against Mucorales isolates and represents another therapeutic option for difficult-to-treat IFI. ISV is a broad-spectrum triazole antifungal II. generation, which is primarily intended for the treatment of invasive aspergillosis and mucormycosis, but in the future it also represents a promising therapeutic option for the treatment of other, rare IFIs (cryptococcosis, infections caused by dimorphic fungi). The article summarizes the basic knowledge and provides a brief overview of the pharmacodynamics, pharmacokinetics, mechanism of action, metabolism, indications, and dosage of isavuconazole in clinical practice. It also includes a brief analysis of selected clinical trials (SECURE, ACTIVE, VITAL) and recommendations of individual international societies.

[目前异戊康唑在治疗侵袭性真菌感染中的作用]。
免疫功能低下患者的治疗和管理方面的重大医学进展目前导致侵袭性真菌感染(IFI)的发生率不断增加。由于抗真菌治疗选择有限,IFI的管理仍然是一个重大挑战。三唑类抗真菌药物isavuconazole (ISV)对Mucorales分离株具有更广泛的活性,是难治性IFI的另一种治疗选择。ISV是一种广谱三唑类抗真菌药物。代,主要用于治疗侵袭性曲霉病和毛霉病,但在未来,它也代表了治疗其他罕见ifi(隐球菌病,由二形真菌引起的感染)的有希望的治疗选择。本文综述了依沙乌康唑的基本知识,并对临床应用中依沙乌康唑的药效学、药代动力学、作用机制、代谢、适应症、剂量等方面作了简要介绍。它还包括对选定的临床试验(SECURE、ACTIVE、VITAL)的简要分析和个别国际学会的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Klinicka mikrobiologie a infekcni lekarstvi
Klinicka mikrobiologie a infekcni lekarstvi Medicine-Infectious Diseases
CiteScore
0.40
自引率
0.00%
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0
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