Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.
Alexander Halim Santoso, Edwin Destra, Yohanes Firmansyah, Susy Olivia Lontoh
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Abstract
Background: Sarcopenia, characterized by a progressive decline in muscle mass and strength, poses significant public health challenges for the elderly, impacting physical performance and quality of life. This study aims to investigate the associations between glucose profile, fasting insulin, renal function, and muscle strength among elderly residents of a single-centered nursing home in Indonesia, identifying potential biomarkers for sarcopenia.
Methods: A cross-sectional analysis was conducted on 31 elderly residents of Santa Anna Nursing Home, with muscle strength measured using handgrip dynamometry and biochemical parameters evaluated through standardized laboratory methods.
Results: Structural Equation Modeling-Partial Least Squares (SEM-PLS) analysis revealed strong negative correlations between glucose profile (β = -0.683, p < 0.01) and fasting insulin (β = -0.208, p < 0.05) with muscle strength, while renal function showed a moderate positive relationship (β = 0.295, p < 0.05).
Conclusion: These findings highlight glucose profile, fasting insulin, and renal function as critical predictors of sarcopenia, offering potential pathways for early detection and targeted interventions. Future research should explore longitudinal assessments and molecular mechanisms to refine sarcopenia prevention strategies in aging populations.
期刊介绍：
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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