Persistently high burden of acute respiratory infections requiring hospitalization in German pediatric hospitals, fall/winter 2023-2024.

IF 5.4 2区 医学 Q1 INFECTIOUS DISEASES
Infection Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI:10.1007/s15010-025-02494-z
Svenja Dreßen, Josephine Schneider, Maren Doenhardt, Natalie Diffloth, Tobias Tenenbaum, Dominik T Schneider, Andreas Trotter, Nicole Toepfner, Reinhard Berner
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引用次数: 0

Abstract

Purpose: During fall 2021, children's hospitals in Germany faced a surge in RSV-related hospitalizations, whereas during fall/winter 2022-2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively assessed severe acute respiratory infections, their causative pathogens, and the resulting disease burden on German children's hospitals for the fall/winter 2023-2024 season.

Methods: From October 3, 2023 through April 16, 2024, children hospitalized with ARI as a primary diagnosis were monitored via a national survey established by the German Society for Pediatric Infectious Diseases (DGPI). Weekly data was collected on total hospital admissions, ARI-related admissions by pathogen (SARS-CoV-2, RSV, influenza, other), ICU admissions with ARI as a primary diagnosis, and respiratory support.

Results: Overall, 23% of German children's hospitals (77/334 centers) submitted 1234 survey reports. ARI-related hospital admissions surged starting in November 2023 and peaked in late December 2023 (53.4% of all admissions), in parallel with a peak in the average number of newly-admitted patients (aNA) with RSV (2.5 aNA). In comparison to the 2022/2023 season, fewer newborns and infants were admitted for ARI (4.7%, p < 0.001/1.9%, p = 0.05) and fewer required ICU treatment (5.3%, p = 0.02/5.6%, p = 0.001 respectively). In 74.9% of ICU patients, ventilation support was required-9.1% less than in the previous season.

Conclusion: The clinical burden on pediatric hospitals and ICUs is strongly influenced by the changing, annually circulating pathogens and affected age group. Therefore, a continuous, systematic, dynamic collection of ARI data is critical for assessing the ARI-related morbidity and the associated burden on health care systems.

2023-2024 年秋冬,德国儿科医院需要住院治疗的急性呼吸道感染病例居高不下。
目的:在2021年秋季,德国儿童医院面临与呼吸道合胞病毒相关的住院人数激增,而在2022-2023年秋冬,呼吸道合胞病毒和流感感染均导致住院人数增加。我们的研究前瞻性地评估了2023-2024秋冬季节德国儿童医院的严重急性呼吸道感染、其致病病原体以及由此产生的疾病负担。方法:从2023年10月3日至2024年4月16日,通过德国儿科传染病学会(DGPI)建立的一项全国调查,监测以ARI为主要诊断的住院儿童。每周收集住院总人数、病原体(SARS-CoV-2、RSV、流感等)导致的ARI相关住院人数、以ARI为主要诊断的ICU住院人数以及呼吸支持的数据。结果:总体而言,23%的德国儿童医院(77/334中心)提交了1234份调查报告。与呼吸道感染相关的住院人数从2023年11月开始激增,并在2023年12月下旬达到峰值(占所有入院人数的53.4%),与此同时,RSV新入院患者(aNA)的平均人数达到峰值(2.5 aNA)。与2022/2023年季节相比,因ARI入院的新生儿和婴儿数量减少(4.7%),p结论:儿科医院和icu的临床负担受到变化的、每年流行的病原体和感染年龄组的强烈影响。因此,持续、系统、动态地收集ARI数据对于评估ARI相关发病率和卫生保健系统的相关负担至关重要。
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来源期刊
Infection
Infection 医学-传染病学
CiteScore
12.50
自引率
1.30%
发文量
224
审稿时长
6-12 weeks
期刊介绍: Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.
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