The Value of P16 Protein Detection in the Screening for High-Grade Squamous Intraepithelial and Higher Lesions of the Cervix by the Combined Detection of HR-HPV and TCT

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2025-03-11 DOI:10.1002/dc.25461

Jiayu Zhou, Mi Tang, Chunhua Lin, Wei Chen

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Abstract

Liquid-based thin layer cytology (TCT) and HR-HPV detection are the most important screening methods for cervical cancer. These two methods have limited sensitivity and specificity, so some cervical lesions are still missed or misdiagnosed. This paper mainly discusses the value of P16 protein detection in cervical cancer screening. In particular, it is effective and practical in high-grade squamous epithelial and above cervical lesions (CINII+). In this retrospective study, the diagnostic specificity and positive predictive value (PPV) of P16 protein detection for cervical CINII+ lesions were significantly higher than that of TCT and HR-HPV detection, and the accuracy was the highest. P16 protein detection can also reduce the rate of missed diagnoses in HR-HPV-negative patients and reduce unnecessary colposcopic biopsies. Our data highlight the feasibility and significance of P16 protein detection in cervical disease screening.

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P16蛋白检测在HR-HPV联合TCT筛查宫颈高级别鳞状上皮内及更高级别病变中的价值

液基薄层细胞学（TCT）和 HR-HPV 检测是最重要的宫颈癌筛查方法。这两种方法的灵敏度和特异性有限，因此仍有一些宫颈病变被漏诊或误诊。本文主要讨论 P16 蛋白检测在宫颈癌筛查中的价值。尤其是对高级别鳞状上皮及以上的宫颈病变（CINII+）有效且实用。在这项回顾性研究中，P16 蛋白检测对宫颈 CINII+ 病变的诊断特异性和阳性预测值（PPV）明显高于 TCT 和 HR-HPV 检测，准确性最高。P16 蛋白检测还能降低 HR-HPV 阴性患者的漏诊率，减少不必要的阴道镜活检。我们的数据凸显了 P16 蛋白检测在宫颈疾病筛查中的可行性和重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.