Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI:10.1097/RLU.0000000000005834

Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo

引用次数: 0

Abstract

A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.