Computational evaluation of the biomechanical effects of position changes in the femoral neck system on Pauwels type III femoral neck fractures: an in silico study.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1493555

Xiang Zhang, Shenghang Zhang, Zhou Zhong, Wen Zhang, Zhongwei Xiong

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引用次数: 0

Abstract

Introduction: Despite the biomechanical advantages of the Femoral Neck System (FNS), improvements in postoperative complication rates have not been significant. This study evaluated the effects of different FNS positions on the biomechanical stability of Pauwels type III femoral neck fractures (FNFs) using finite element analysis (FEA).

Methods: Pauwels type III FNF models fixed with different FNS positions were constructed using various bolt lengths, bolt positions, and axis-bolt angles. Biomechanical parameters, including stiffness, maximum implant von Mises stress (MIVS), maximum interfragmentary shear stress (MISS), and maximum interfragmentary gap (MIG), were analyzed by simulating early postoperative weight-bearing. Entropy scoring was used to rank the performance of different fixation positions to determine the optimal FNS implantation position.

Results: Compared with that of the standard model, the biomechanical stability changed when FNS positioning was altered. Among all the evaluated parameters, MIG had the highest weight (60.04%). In the lateral view, fracture fixation was most stable when the bolt was rotated 5° anteriorly relative to the femoral neck axis (composite score = 0.87). However, stability was poorer when the bolt was rotated 9° inward relative to the femoral neck axis (composite score = 0.13).

Discussion: The MIG is an important biomechanical parameter for assessing the stability of different FNS positions when treating FNFs. Shortening the distance between the bolt and the subchondral bone, upward movement, external rotation, and anterior rotation of the bolt can help improve the stability of the FNS in the treatment of Pauwels III FNFs.

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.