Positive Relationship between Total Calcium and Hyperuricemia in Adults: a Cross-Sectional Study.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-03-01 DOI:10.7754/Clin.Lab.2024.240726

Hong Lei, Haining Guan

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引用次数: 0

Abstract

Background: Calcium (CA) is crucial for a wide range of biological functions. However, the correlation between total calcium and hyperuricemia in US adults remains unclear. This study aimed to assess whether total calcium is associated with hyperuricemia.

Methods: Based on data from the NHANES (2011 - 2018), we conducted a cross-sectional study involving 20,028 US adults aged 18 or older. Logistic regression, fitting smooth curves, and interaction effects were utilized to support the research objectives.

Results: Regression analyses demonstrated a positive relation between total calcium and hyperuricemia (p < 0.001). Positive association between levels of total calcium and the risk of hyperuricemia was observed after full adjustment for all the confounding variables (odds ratio: 13.28, 95% confidence interval: 10.38 - 16.99, p < 0.001). The interaction of total calcium and hyperuricemia with age and gender was significant (p values for interaction < 0.05), while there was no interaction in other subgroups (p-values for interaction > 0.05). In addition, curve fitting after adjusting for all the confounding variables indicated a nonlinear positive correlation between total calcium and hyperuricemia (p for nonlinearity = 0.024).

Conclusions: The present cross-sectional study revealed that a nonlinear positive association existed between total calcium and hyperuricemia in US adults. The results could be beneficial for the management and treatment of hyperuricemia.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.