Correlation of Plasma α-Synuclein with Cerebral Blood Flow in Patients with Parkinson Disease with Freezing of Gait.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-03-01 DOI:10.7754/Clin.Lab.2024.240756

Yue Ti, FangFang Liu, Yan Ma, QiaoLi Zhu, ChuangZhou Xie, HePing Xia, Jing Chen

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引用次数: 0

Abstract

Background: The aim of this study was to investigate the relationship between plasma α-synuclein (α-syn) levels and cerebral blood flow in patients with Parkinson disease (PD) with freezing of gait (FOG).

Methods: A total of 120 cases of PD patients were selected, and FOG was evaluated according to the FOG questionnaire, with a score of > 3 classified as FOG. Based on the evaluation results, the patients were divided into the PD-FOG group (58 cases) and the PD-NFOG group (62 cases). Cerebral blood flow parameters including cerebral blood flow velocity (CBFV) of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and gain were monitored, and plasma α-syn levels were measured by enzyme-linked immunosorbent assay. Multifactorial logistic regression analysis was performed to explore the influencing factors of patients with Parkinson's with FOG.

Results: FOG occurred in 58 out of 120 cases of PD patients, and the prevalence rate amounted to 48.3%. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery were slower, phase difference was smaller, and plasma α-syn level was higher in the PD-FOG group. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and plasma α-syn level were independent influences on FOG in PD patients.

Conclusions: Decreased cerebrovascular reserve function and increased plasma α-synuclein level increase the risk of FOG in PD patients.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.