Xingqin Huang, Jiasi Zhang, Na Shen, Xia Wang, Linglin Jiang, Xiaofen Zeng, Keyu Liu
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引用次数: 0
Abstract
Background: Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this study was to investigate the correlation of TCF3::PBX1 fusion with multiple clefts nuclei of blasts in patients with B-ALL/LBL.
Methods: We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears of 145 patients prepared at the time of initial diagnosis of B-ALL/LBL based on the results of testing for the TCF3::PBX1 fusion.
Results: We investigated the association among this morphological phenotype and hematologic findings, disease markers, fusions of TCF3::PBX1, BCR::ABL1, and ETV6::RUNX1, KMT2A rearrangement, and no such fusions and rearrangements. Multiple clefts nuclei of blasts were found in 13 patients (8.97%) diagnosed with B-ALL/ LBL. Positive association between multiple clefts nuclei of blasts and TCF3::PBX1 fusion in patients with B-ALL/ LBL was observed after full adjustment for all the confounding variables (p < 0.05).
Conclusions: The morphology of multiple clefts nuclei in blasts was strongly correlated with TCF3::PBX1 fusion in patients with B-ALL/LBL. Therefore, testing for TCF3::PBX1 fusions is recommended for patients with the morphology of multiple clefts nuclei in blasts.
期刊介绍:
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.