Characteristics and Epidemiological Analysis of Enterococcal Infection from Beijing Teaching Hospital in China, 2010 - 2021.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-03-01 DOI:10.7754/Clin.Lab.2024.240801

Zeqiang Xie, Jiyong Jian, Liang Chen

{"title":"Characteristics and Epidemiological Analysis of Enterococcal Infection from Beijing Teaching Hospital in China, 2010 - 2021.","authors":"Zeqiang Xie, Jiyong Jian, Liang Chen","doi":"10.7754/Clin.Lab.2024.240801","DOIUrl":null,"url":null,"abstract":"Background: The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.Methods: In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed. Whonet 5.6 software and SPSS 20.0 were used for data analysis.Results: Among the 3,455 pathogens, the top three were Enterococcus faecium (1,819 strains, 52.65%), Enterococcus faecalis (1,310 strains, 37.92%), and Enterococcus gallinarum (1,203 strains, 3.47%). There were more strains from females (1,808 strains, 52.33%) than from males (1,647 strains, 47.67%). Furthermore, 1,446 strains (41.85%) were isolated from urine samples, and the resistance rates to vancomycin and linezolid were 15.72% and 0.58%, respectively. The resistance rates to penicillin, ampicillin, ciprofloxacin, and levofloxacin were higher than 50%.Conclusions: Enterococcus faecium was the main pathogen of enterococcal infection. Most of them were cultured in urine. The multi-drug resistance was high. Vancomycin-resistant Enterococcus cannot be ignored. Bacterial resistance monitoring provides an important theoretical basis for clinicians to rationally use antibiotics and prevent nosocomial infection.","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240801","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.

Methods: In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed. Whonet 5.6 software and SPSS 20.0 were used for data analysis.

Results: Among the 3,455 pathogens, the top three were Enterococcus faecium (1,819 strains, 52.65%), Enterococcus faecalis (1,310 strains, 37.92%), and Enterococcus gallinarum (1,203 strains, 3.47%). There were more strains from females (1,808 strains, 52.33%) than from males (1,647 strains, 47.67%). Furthermore, 1,446 strains (41.85%) were isolated from urine samples, and the resistance rates to vancomycin and linezolid were 15.72% and 0.58%, respectively. The resistance rates to penicillin, ampicillin, ciprofloxacin, and levofloxacin were higher than 50%.

Conclusions: Enterococcus faecium was the main pathogen of enterococcal infection. Most of them were cultured in urine. The multi-drug resistance was high. Vancomycin-resistant Enterococcus cannot be ignored. Bacterial resistance monitoring provides an important theoretical basis for clinicians to rationally use antibiotics and prevent nosocomial infection.

查看原文本刊更多论文

2010 - 2021年北京教学医院肠球菌感染特点及流行病学分析

背景：了解肠球菌的分布及耐药特点，为临床应用抗生素及医院感染控制提供可靠依据。方法：收集2010年1月至2021年12月分离的3455株肠球菌。采用Bruker MALDI生物分型仪、MICROSCAN walkaway 40分析系统、Vitek-2紧凑型自动药敏分析仪对菌株进行鉴定和药敏试验，并对结果进行分析。采用Whonet 5.6软件和SPSS 20.0进行数据分析。结果：在3455种病原菌中，排在前三位的分别是粪肠球菌（1819株，占52.65%）、粪肠球菌（1310株，占37.92%）和鸡肠球菌（1203株，占3.47%）。女性感染株（1808株，52.33%）多于男性感染株（1647株，47.67%）。从尿样中分离出1446株（41.85%），对万古霉素和利奈唑胺的耐药率分别为15.72%和0.58%。对青霉素、氨苄西林、环丙沙星、左氧氟沙星的耐药率均大于50%。结论：粪肠球菌是肠球菌感染的主要病原菌。大多数在尿中培养。耐多药性高。万古霉素耐药肠球菌不容忽视。细菌耐药性监测为临床医生合理使用抗生素和预防院内感染提供了重要的理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.