The impact of low dietary inflammatory index diet on clinical parameters in patients with chronic kidney disease: a retrospective comparative study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Weijuan Pan, Jian Feng
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引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) poses a significant global health challenge. Inflammation plays a central role in the pathogenesis and progression of CKD, which has been proved to be affected by dietary patterns. To understand how dietary inflammatory index (DII) impacts the disease course and clinical parameters, we aim to explore the relationship between DII and multiple clinical parameters in a specific cohort of CKD patients, and to provide insights into the potential of dietary for managing CKD.

Methods: This retrospective comparative study included 145 CKD patients, categorized into a low DII group (n = 77) and a high DII group (n = 68) based on their DII values. Clinical data, including demographic characteristics, laboratory parameters, dietary intake, inflammatory markers, renal function, and adverse events, were collected and compared between the two groups.

Results: The demographic characteristics were comparable between the groups. The low DII group had significantly lower serum creatinine, phosphorus, and potassium levels (P < 0.05) and higher hemoglobin levels compared to the high DII group. Protein intake was significantly higher in the high DII group (P < 0.001), while fiber intake was significantly higher in the low DII group (P = 0.022). Inflammatory markers, including CRP, TNF-α, fibrinogen, procalcitonin, and WBC, were significantly lower in the low DII group (P < 0.05). The low DII group also showed better renal function, as indicated by higher GFR and lower urinary albumin excretion (P < 0.05). Correlation analysis revealed significant relationships between protein intake and inflammation markers (CRP, TNF-α, fibrinogen) and a negative correlation with GFR. Regression analysis confirmed that DII was independently associated with CRP, GFR, and urinary albumin excretion, while protein intake remained significantly correlated with these outcomes.

Conclusion: A low DII diet may be associated with improved clinical parameters, inflammatory markers, and renal function in CKD patients. Tailored nutritional strategies focusing on modulating inflammatory status through low DII diets may offer promising avenues for improving renal function, mitigating inflammation, and enhancing overall well-being in individuals with CKD.

Clinical trial number: Not applicable.

低炎症指数饮食对慢性肾病患者临床参数的影响:一项回顾性比较研究
背景:慢性肾脏疾病(CKD)是一个重大的全球健康挑战。炎症在CKD的发病和进展中起着核心作用,已被证明受饮食模式的影响。为了了解饮食炎症指数(dietary inflammatory index, DII)如何影响病程和临床参数,我们旨在探讨特定CKD患者队列中DII与多个临床参数之间的关系,并为饮食管理CKD的潜力提供见解。方法:本回顾性比较研究纳入145例CKD患者,根据其DII值分为低DII组(n = 77)和高DII组(n = 68)。收集并比较两组患者的临床数据,包括人口统计学特征、实验室参数、饮食摄入、炎症标志物、肾功能和不良事件。结果:两组人口统计学特征具有可比性。低DII组血清肌酐、磷和钾水平显著降低(P结论:低DII饮食可能与改善CKD患者的临床参数、炎症标志物和肾功能有关。量身定制的营养策略侧重于通过低DII饮食来调节炎症状态,这可能为CKD患者改善肾功能、减轻炎症和提高整体幸福感提供了有希望的途径。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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