Cortical tinnitus evaluation using functional near-infrared spectroscopy

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-08 DOI:10.1016/j.brainres.2025.149561

Mariana Lopes Martins , Edgard Morya , Liliane Kaline Araújo de Lima , Isabelle Costa de Vasconcelos , Sheila Andreoli Balen , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa

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引用次数: 0

Abstract

Functional near-infrared spectroscopy (fNIRS) estimates the cortical hemodynamic response induced by sound stimuli. fNIRS can be used to understand the symptomatology of tinnitus and consequently provide effective ways of evaluating and treating the symptom.

Objective

Compare the changes in the oxy-hemoglobin and deoxy-hemoglobin concentration of individuals with and without tinnitus using auditory stimulation by fNIRS.

Methods

A tinnitus group (n = 23) and a control group (n = 23) were evaluated by an auditory task for assessing sound-evoked auditory cortex activity. The fNIRS was composed of 20 channels arranged into 4x2 arrays over the frontal, temporal and parietal cortices. Then, a passive listening block-paradigm design was adopted with reoccurring blocks of tasks with 15 s interspersed with randomized silence periods between 15–25 s.

Results

There was a significant difference in the condition (type of sound), region of interest (ROI) and channel. As well as significant interaction in group and condition, and group and channel. The Tinnitus Frequency decreased HbO levels, while other sounds (white noise − WN and 1KHZ) increased HbO levels. All conditions differed from each other, except 1KHz with Baseline (silence) in the control group. Regarding the channels, the frontal channels (1, 3, and 11) differed in the tinnitus group, while in the control group a difference was observed in the channels of the frontal, temporal and parietal regions.

Conclusion

The type of sound presented, and brain region influenced the variations in HbO levels, but there was no difference between tinnitus and control participants. The tinnitus loudness, annoyance, and severity showed a weak correlation with variations in HbO levels.

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功能性近红外光谱评价皮质耳鸣。

功能近红外光谱（fNIRS）估计由声音刺激引起的皮质血流动力学反应。fNIRS可用于了解耳鸣的症状，从而提供评估和治疗耳鸣症状的有效方法。目的：比较fNIRS听觉刺激对耳鸣患者和非耳鸣患者氧血红蛋白和脱氧血红蛋白浓度的影响。方法：对耳鸣组（n = 23）和对照组（n = 23）进行声音诱发听觉皮层活动评估。fNIRS由20个通道组成，以4x2阵列排列在额叶、颞叶和顶叶皮层上。然后，采用被动倾听块范式设计，重复出现15个 s的任务块，并在15-25 s之间随机穿插沉默期。结果：在条件（声音类型）、感兴趣区域（ROI）和通道上有显著性差异。以及群体和条件，群体和渠道之间的显著互动。耳鸣频率降低HbO水平，而其他声音（白噪音- WN和1KHZ）增加HbO水平。所有条件彼此不同，除了1KHz的基线（沉默）在对照组。通道方面，耳鸣组的额叶通道（1、3、11）存在差异，而对照组的额叶、颞叶和顶叶通道存在差异。结论：声音类型和脑区影响耳鸣组HbO水平的变化，但耳鸣组与对照组无差异。耳鸣响度、恼人程度和严重程度与HbO水平的变化呈弱相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.