Prophylactic Tranexamic Acid Use in Orthognathic Surgery: A Systematic Review and Meta-analysis.

IF 2 3区医学 Q2 SURGERY

Aesthetic Plastic Surgery Pub Date : 2025-03-10 DOI:10.1007/s00266-025-04738-7

Hooman Baghaie, Khilan Shukla, Jennifer Stone, Omar Breik, Zachary Munn

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引用次数: 0

Abstract

Background: The objective of this systematic review and meta-analysis was to assess the effects of tranexamic acid (TXA) on bleeding and thromboembolic events in orthognathic surgery out.

Methods: Three electronic databases (PubMed, Web of Science, and Cochrane Library) were searched until 01/06/2024.

Results: Nine randomised controlled trials and two cohort studies were included for pooled analysis. Compared with the control group, the TXA group showed a mean reduction in intraoperative blood loss of 171.30 ml (p < 0.00001; 95% CI, 197.58-145.02 ml). Systemic tranexamic acid use was associated with reduced operative time by a mean of14.5 minutes (p < 0.0001; 95% CI, 20.89-8.02 mins) and reduction in the need for transfusion OR= 0.33 (p < 0.01; 95% CI, 0.14-0.77).

Conclusion: This systematic review and meta-analysis supports the prophylactic use of tranexamic acid during orthognathic surgery in reducing blood loss, operative time and the risk of needing blood transfusions without increasing risk of thromboembolic complications.

Level of evidence i: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266 .

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来源期刊

Aesthetic Plastic Surgery 医学-外科

CiteScore

4.40

自引率

25.00%

发文量

479

审稿时长

3 months

期刊介绍： Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP). Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships. Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.