A Comprehensive Analysis of Market Forms and Analytical Methods for Metformin Formulations

IF 1.8 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Saravana Muthu Kumar Pandian, Punniyakoti V. Thanikachalam, Deviga Kaliyappan, Anandarajagopal Kalusalingam
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引用次数: 0

Abstract

Metformin has been a cornerstone in the management of type 2 diabetes mellitus (T2DM) for more than 50 years, either alone or in combination with other therapies. This oral antihyperglycemic agent, also known as dimethylbiguanide, plays a crucial role in regulating noninsulin-dependent diabetes mellitus and is widely prescribed globally for various medical conditions. Recent advancements in its formulations have aimed to increase its effectiveness, tolerance, and nonglycemic effects. This review critically evaluates the analytical methods used to assess metformin formulations, including chromatographic and spectroscopic techniques, with a focus on sensitivity, specificity, and reliability. Comprehensive literature from various scientific databases was searched to gather information on metformin. Various formulations of metformin HCl, including hydrogels, solid dosage forms, mucoadhesive patches, lipospheres, and topical preparations, offer advantages like sustained release, improved bioavailability, and wound-healing potential. Analytical methods like RP-HPLC and UV–visible spectroscopy ensure the safety, stability, and accurate quantification of these formulations. These approaches support personalized treatment of T2DM, enhancing blood sugar control, therapeutic efficacy, and patient outcomes. This review offers valuable insights into metformin formulations and analytical aspects that researchers and pharmaceutical experts benefit in the further development and evaluation of metformin formulations.

50 多年来,二甲双胍一直是治疗 2 型糖尿病(T2DM)的基石,既可单独使用,也可与其他疗法联合使用。这种口服降糖药也被称为二甲双胍,在调节非胰岛素依赖型糖尿病方面发挥着重要作用,在全球范围内被广泛用于治疗各种病症。近年来,其制剂的进步旨在提高其有效性、耐受性和非降糖作用。本综述严格评估了用于评估二甲双胍制剂的分析方法,包括色谱和光谱技术,重点关注灵敏度、特异性和可靠性。为了收集有关二甲双胍的信息,我们从各种科学数据库中搜索了大量文献。盐酸二甲双胍的各种制剂,包括水凝胶、固体制剂、粘液贴片、脂球和局部制剂,都具有持续释放、生物利用度提高和伤口愈合潜力等优点。RP-HPLC 和紫外可见光谱等分析方法可确保这些制剂的安全性、稳定性和准确定量。这些方法可支持 T2DM 的个性化治疗,提高血糖控制、疗效和患者预后。本综述提供了有关二甲双胍制剂和分析方面的宝贵见解,有助于研究人员和制药专家进一步开发和评估二甲双胍制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Chromatography
Biomedical Chromatography 生物-分析化学
CiteScore
3.60
自引率
5.60%
发文量
268
审稿时长
2.3 months
期刊介绍: Biomedical Chromatography is devoted to the publication of original papers on the applications of chromatography and allied techniques in the biological and medical sciences. Research papers and review articles cover the methods and techniques relevant to the separation, identification and determination of substances in biochemistry, biotechnology, molecular biology, cell biology, clinical chemistry, pharmacology and related disciplines. These include the analysis of body fluids, cells and tissues, purification of biologically important compounds, pharmaco-kinetics and sequencing methods using HPLC, GC, HPLC-MS, TLC, paper chromatography, affinity chromatography, gel filtration, electrophoresis and related techniques.
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