Effect of Glass Ionomer Filler Size on Fluoride Release, Antiplaque Properties, and Abrasive Effects of Toothpaste

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2025-03-11 DOI:10.1002/cre2.70109

Behnaz Vahidi, Homayoon Alaghehmand, Hamed Tashakkorian, Seyedali Seyedmajidi, Maryam Ghasempour

{"title":"Effect of Glass Ionomer Filler Size on Fluoride Release, Antiplaque Properties, and Abrasive Effects of Toothpaste","authors":"Behnaz Vahidi, Homayoon Alaghehmand, Hamed Tashakkorian, Seyedali Seyedmajidi, Maryam Ghasempour","doi":"10.1002/cre2.70109","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aimed to assess the impact of incorporating glass ionomer fillers of varying sizes on fluoride release, antiplaque properties, and the abrasive effects of toothpaste.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>In this laboratory study, three toothpaste samples containing glass ionomer filler particles (0.5, 5 µm, and a hybrid combination of equal proportions of both fillers) were tested, along with a base toothpaste without fillers or fluoride and a commercial toothpaste (Colgate Total) as controls. Fluoride release was measured using a fluoride ion-selective electrode. Antiplaque properties were assessed by evaluating the effect of toothpaste on cultured saliva in tissue culture plates, with optical density measured using an ELISA reader. Abrasive effects were analyzed by changes in enamel thickness of bovine teeth using a three-body wear test. Data were analyzed with ANOVA and Tukey's tests in SPSS software at a 0.05 significance level.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Toothpaste containing 0.5 µm fillers showed the highest fluoride release, whereas the lowest release was associated with 5 µm fillers. All formulations demonstrated antiplaque activity, though differences among filler-containing toothpastes were not statistically significant (<i>p</i> > 0.05). Enamel abrasion differed significantly among the samples (<i>p</i> < 0.001), with the greatest abrasion observed for toothpaste containing 5 µm fillers and the least abrasion observed for 0.5 µm fillers.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Incorporating glass ionomer fillers into toothpaste formulations provides fluoride release and antiplaque effects comparable to those of commercial toothpaste. Smaller filler sizes enhance fluoride release and reduce abrasiveness, though filler size does not significantly influence antiplaque efficacy.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70109","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This study aimed to assess the impact of incorporating glass ionomer fillers of varying sizes on fluoride release, antiplaque properties, and the abrasive effects of toothpaste.

Materials and Methods

In this laboratory study, three toothpaste samples containing glass ionomer filler particles (0.5, 5 µm, and a hybrid combination of equal proportions of both fillers) were tested, along with a base toothpaste without fillers or fluoride and a commercial toothpaste (Colgate Total) as controls. Fluoride release was measured using a fluoride ion-selective electrode. Antiplaque properties were assessed by evaluating the effect of toothpaste on cultured saliva in tissue culture plates, with optical density measured using an ELISA reader. Abrasive effects were analyzed by changes in enamel thickness of bovine teeth using a three-body wear test. Data were analyzed with ANOVA and Tukey's tests in SPSS software at a 0.05 significance level.

Results

Toothpaste containing 0.5 µm fillers showed the highest fluoride release, whereas the lowest release was associated with 5 µm fillers. All formulations demonstrated antiplaque activity, though differences among filler-containing toothpastes were not statistically significant (p > 0.05). Enamel abrasion differed significantly among the samples (p < 0.001), with the greatest abrasion observed for toothpaste containing 5 µm fillers and the least abrasion observed for 0.5 µm fillers.

Conclusions

Incorporating glass ionomer fillers into toothpaste formulations provides fluoride release and antiplaque effects comparable to those of commercial toothpaste. Smaller filler sizes enhance fluoride release and reduce abrasiveness, though filler size does not significantly influence antiplaque efficacy.

Abstract Image

查看原文本刊更多论文

玻璃离子填料尺寸对牙膏氟化物释放、抗菌斑性能和磨蚀效果的影响

本研究旨在评估加入不同尺寸的玻璃离子填料对牙膏氟化物释放、抗牙菌斑性能和磨蚀效果的影响。在本实验室研究中，测试了三种含玻璃离子填料颗粒（0.5、5µm和两种填料的混合比例相等）的牙膏样品，以及一种不含填料或氟化物的基础牙膏和一种商业牙膏（高露洁Total）作为对照。使用氟离子选择电极测量氟化物释放。通过评估牙膏对组织培养板中培养唾液的影响来评估抗菌斑特性，使用ELISA读取器测量光密度。采用三体磨损试验方法，对牛牙釉质厚度的变化进行了磨料效果分析。数据分析采用SPSS软件的方差分析和Tukey检验，显著性水平为0.05。结果含氟量为0.5µm的牙膏氟释放量最高，含氟量为5µm的牙膏氟释放量最低。所有配方都显示出抗菌斑活性，尽管含填充物牙膏之间的差异没有统计学意义（p > 0.05）。釉质磨损在不同样品之间差异显著（p < 0.001），含5µm填料的牙膏磨损最大，含0.5µm填料的牙膏磨损最小。结论在牙膏配方中加入玻璃离子填料具有与市售牙膏相当的氟释放和抗牙菌斑效果。较小的填充物尺寸增强氟化物释放并减少磨蚀性，但填充物尺寸对抗牙菌斑效果没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.