Evaluation of Antibacterial Activity of Different Porphyrins Containing Transition Metals at the Core: Unveiling the Potent Metalloporphyrins as Antimicrobial Agents

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-03-10 DOI:10.1002/aoc.70115

Midhuna Subash, Rachel Bijoy, Ankita Naykodi, Mukund S. Chorghade, Bhaskar N. Thorat

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Abstract

The foundation of healthcare has been the use of antibiotics to treat bacterial infections; however, the growing number of infections resistant to these drugs has raised serious concerns. Innovative antimicrobial strategies that are safe, minimally invasive, and able to act quickly and efficiently are needed to address this urgent problem and provide a substitute for conventional antibiotics in the fight against this growing health emergency. Metalloporphyrins are emerging photosensitizers, utilized in antimicrobial photodynamic therapy, using visible light and photosensitive compounds to cause oxidative damage to microbial organisms. Metalloporphyrins are minimally toxic molecules that can target microbial pathogens through a variety of distinct mechanisms. We synthesized an electronically activated and sterically protected catalyst, meso-tetrakis(2,6-dichlorophenyl-β-octabromo) porphyrins and inserted different metals into the porphyrin cavity. Evaluation of the antibacterial activity of our catalyst towards various Gram-positive and Gram-negative bacteria revealed bactericidal activity.

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.