Use of dielectric nanoparticles doped with rare-earth ions for the treatment of melanoma with non-contact exposure to near-IR laser radiation (in-vivo experiments)

IF 1.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Bulletin of Materials Science Pub Date : 2025-03-12 DOI:10.1007/s12034-025-03399-1

POLINA A RYABOCHKINA, SVETLANA A KHRUSHCHALINA, OLEG A KULIKOV, VASILISA I SHLYAPKINA, VALENTIN P AGEEV, NATALIYA YU TABACHKOVA, VARVARA O VESELOVA

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Abstract

Excitation of dielectric nanoparticles highly doped with rare-earth (RE) ions by intense laser radiation can lead to their significant heating. This effect can be used to enhance the thermal effect of laser radiation on biological tissues. This work is devoted to study the features of a thermal emission in compounds based on zirconium dioxide doped with various RE ions in order to identify the type of RE ion and excitation conditions that are most suitable for the described application. In-vitro experiments using the particles studied in this work and earlier, showed that the enhancement of the thermal effect of laser radiation is most pronounced for ytterbium-containing particles and radiation with a wavelength of 970 nm. As a result of in-vivo experiments (on mice), the possibility of using ytterbium-containing particles when excited by laser radiation with a wavelength of 970 nm for the treatment of B16 melanoma has been demonstrated.

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来源期刊

Bulletin of Materials Science 工程技术-材料科学：综合

CiteScore

3.40

自引率

5.60%

发文量

209

审稿时长

11.5 months

期刊介绍： The Bulletin of Materials Science is a bi-monthly journal being published by the Indian Academy of Sciences in collaboration with the Materials Research Society of India and the Indian National Science Academy. The journal publishes original research articles, review articles and rapid communications in all areas of materials science. The journal also publishes from time to time important Conference Symposia/ Proceedings which are of interest to materials scientists. It has an International Advisory Editorial Board and an Editorial Committee. The Bulletin accords high importance to the quality of articles published and to keep at a minimum the processing time of papers submitted for publication.