Fe3O4@SiO2–Pr–THAM–(OSO3H)3: a novel magnetically separable catalyst for the synthesis of 4H-chromenes and their antioxidant and antibacterial study

IF 2.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-01-26 DOI:10.1007/s11164-025-05506-7

Rutuja Ramesh Zond, Arati Subhash Kulkarni, Suvarna Raghunath Umape, Padma Babulal Dandge, Reshma Pandit Yadav, Nitin Maruti Naik, Vishal Hindurao Thorat, Prafulla Balkrishna Choudhari, Shankar Poshatti Hangirgekar, Sandeep Ashok Sankpal

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引用次数: 0

Abstract

The present research delineates the synthesis and catalytic assessment of a novel Fe₃O₄@SiO₂–Pr–THAM–(OSO₃H)₃ magnetic nanoparticles. The structural conformation of as-prepared Fe₃O₄@SiO₂–Pr–THAM–(OSO₃H)₃ nanoparticles was evaluated using numerous analytical methods like Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy, X-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis. The catalytic potential of Fe₃O₄@SiO₂–Pr–THAM–(OSO₃H)₃ was tested for the syntheses of 4H-chromenes through one-pot condensation of 2-hydroxybenzaldehyde, cyclic 1,3-diketones, and 4-hydroxycoumarin in aqueous solution at 50 °C. The current methodology offers the benefits of superior catalytic activity, the utilization of environmentally friendly solvents, easy work-up procedure, excellent yield, magnetic separation, shorter reaction times, and catalyst reusability with no significant loss in potency after six cycles. The synthesized 4H-chromene derivatives were screened for antibacterial and in vitro antioxidant study and were found to have promising activities supported by molecular docking studies.

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.