Intraoperative evaluation using a multimodality probe of temperature-dependent neurovascular modulation during focal brain cooling

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-03-08 DOI:10.1016/j.clinph.2025.02.262

Takao Inoue , Sadahiro Nomura , Toshitaka Yamakawa , Sayuki Takara , Hirochika Imoto , Yuichi Maruta , Masatsugu Niwayama , Michiyasu Suzuki

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引用次数: 0

Abstract

Objective

This study aimed to assess the effects of focal brain cooling (FBC) on human brain tissue through use of multiple sensing techniques by monitoring cerebrovascular activity and brain temperature.

Methods

Intraoperative brain activity monitoring using a multimodality probe capable of measuring brain temperature, electrocorticography (ECoG) and changes in cerebral hemoglobin concentration was performed in 13 patients with refractory epilepsy. Brain temperature and neurovascular activity were measured beneath and surrounding the FBC device. Data were categorized into three temperature ranges [low-temperature range (LTR, <18 °C), moderate-temperature range (MTR, 18 °C–28 °C), and high-temperature range (HTR, >28 °C)] for analysis.

Results

Changes in oxyhemoglobin (ΔO₂Hb) and deoxyhemoglobin (ΔHHb) across the temperature ranges showed a U-shape and inverted U-shape pattern, respectively. ΔO₂Hb decreased and ΔHHb increased in the MTR, reflecting enhanced neuronal activity and increased oxygen consumption. Conversely, ΔO₂Hb increased and ΔHHb decreased in the LTR, indicating suppressed neuronal activity and reduced oxygen consumption. These findings highlight the temperature-dependent modulation of neurovascular activity by FBC, driven by distinct non-linear patterns.

Conclusions

FBC selectively influenced brain electrical activity and hemoglobin concentration, highlighting its subtle effects on neurovascular dynamics.

Significance

These findings provide critical insights into optimizing cooling strategies for neurological disorders using multimodality probes and FBC devices.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.