Changes in the expression of sirtuin type 1 (SIRT1) and its downstream pathways following retinal damage induced by blue light-emitting diodes (LEDs): Medical thermal radiation image inspection

IF 5.1 3区工程技术 Q2 ENERGY & FUELS

Thermal Science and Engineering Progress Pub Date : 2025-03-07 DOI:10.1016/j.tsep.2025.103480

Leilei Lin , Qishan Zheng , Yao Zong , Yanming Dong , Qianying Gao

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引用次数: 0

Abstract

With the popularization of electronic products featuring light-emitting diodes (LEDs), such as computers and smartphones, exposure to blue light has substantially increased. The present study aimed to clarify the mechanism underlying blue light-induced retinal injury and protection conferred by sirtuin type 1 (SIRT1) in mouse retinal pigment epithelial cells and human retinal pigment epithelial (ARPE-19) cells. The C57/BL mice for 24 h and ARPE-19 cells for 3 h were exposed to blue and white light (5000 lx). Exposure to the blue light affected the morphology and function of the mouse retinal cells after 24 h, and these effects remained after 6 mon. Blue light exposure on the ARPE-19 cells or mice altered the expression of SIRT1. It also affected the expression of Extracellular Regulated Protein Kinases(ERK), p38, p53, caspase 3, protein kinase C α (PKC-α), protein kinase B(AKT) and Superoxide Dismutase(SOD). Blue light exposure may induce apoptosis by activation of ERK, p38, p53 and caspase 3 signalling pathways and down-regulation of the expression of SOD and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways. SIRT1 may protect against blue light-induced damage via regulation of the above signal transduction pathways and inhibition of oxidative stress.

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来源期刊

Thermal Science and Engineering Progress Chemical Engineering-Fluid Flow and Transfer Processes

CiteScore

7.20

自引率

10.40%

发文量

327

审稿时长

41 days

期刊介绍： Thermal Science and Engineering Progress (TSEP) publishes original, high-quality research articles that span activities ranging from fundamental scientific research and discussion of the more controversial thermodynamic theories, to developments in thermal engineering that are in many instances examples of the way scientists and engineers are addressing the challenges facing a growing population – smart cities and global warming – maximising thermodynamic efficiencies and minimising all heat losses. It is intended that these will be of current relevance and interest to industry, academia and other practitioners. It is evident that many specialised journals in thermal and, to some extent, in fluid disciplines tend to focus on topics that can be classified as fundamental in nature, or are ‘applied’ and near-market. Thermal Science and Engineering Progress will bridge the gap between these two areas, allowing authors to make an easy choice, should they or a journal editor feel that their papers are ‘out of scope’ when considering other journals. The range of topics covered by Thermal Science and Engineering Progress addresses the rapid rate of development being made in thermal transfer processes as they affect traditional fields, and important growth in the topical research areas of aerospace, thermal biological and medical systems, electronics and nano-technologies, renewable energy systems, food production (including agriculture), and the need to minimise man-made thermal impacts on climate change. Review articles on appropriate topics for TSEP are encouraged, although until TSEP is fully established, these will be limited in number. Before submitting such articles, please contact one of the Editors, or a member of the Editorial Advisory Board with an outline of your proposal and your expertise in the area of your review.