Fluorescent polymer nanoparticles for targeted drug delivery and synergistic osteosarcoma therapy

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2025-03-07 DOI:10.1016/j.jics.2025.101660

Yunfei Lin, Bing Wang

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引用次数: 0

Abstract

Osteosarcoma (OS) is a malignant bone tumor that predominantly affects adolescents, with symptoms including localized pain and swelling. DKK1, an antagonist of the Wnt signaling pathway, plays a pivotal role in tumor progression. This study presents a novel fluorescent nanocarrier (PLA-PEG-RhB) designed for the targeted delivery and controlled release of a therapeutic combination of compound 1 and doxorubicin (DOX) (CP1@1@DOX). The PLA-PEG-RhB carrier, composed of rhodamine B, PLA, and PEG, enhances drug bioavailability and targeting while enabling real-time fluorescence tracking. The synergistic effect of compound 1 and DOX within the nanocarrier significantly inhibits osteosarcoma cell proliferation and reduces tumor growth, minimizing toxicity to healthy cells. In vitro, PLA-PEG-RhB@CP1@1@DOX suppressed osteosarcoma cell proliferation by regulating DKK1 expression and blocking key tumor progression pathways. This study highlights the potential of fluorescent nanomedicine combined with targeted chemotherapy for osteosarcoma treatment.

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靶向药物递送和骨肉瘤协同治疗的荧光聚合物纳米颗粒

骨肉瘤（OS）是一种主要影响青少年的恶性骨肿瘤，其症状包括局部疼痛和肿胀。DKK1是Wnt信号通路的拮抗剂，在肿瘤进展中起关键作用。本研究提出了一种新型荧光纳米载体（PLA-PEG-RhB），设计用于靶向递送和控制释放化合物1和阿霉素（DOX）（CP1@1@DOX）的治疗组合。PLA-PEG- rhb载体由罗丹明B、PLA和PEG组成，增强了药物的生物利用度和靶向性，同时实现了实时荧光跟踪。化合物1和DOX在纳米载体内的协同作用显著抑制骨肉瘤细胞增殖，降低肿瘤生长，最大限度地减少对健康细胞的毒性。在体外，PLA-PEG-RhB@CP1@1@DOX通过调节DKK1表达和阻断关键肿瘤进展途径抑制骨肉瘤细胞增殖。本研究强调了荧光纳米药物联合靶向化疗治疗骨肉瘤的潜力。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.