Interrelationships between glucose metabolism and gonadal hormones in female first-episode patients with schizophrenia

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-03-04 DOI:10.1016/j.jpsychores.2025.112087

Jing Yao , Fengchun Wu , Meihong Xiu

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引用次数: 0

Abstract

Background

Schizophrenia (SCZ) is a complex mental disorder that typically emerges in late adolescence or early adulthood. The underlying molecular mechanisms of SCZ remain unclear. There is growing evidence supporting the involvement of abnormalities in metabolic and endocrine systems in the pathophysiology of SCZ. Our study was designed to explore the interrelationship between gonadal hormones and glucose metabolism in patients with SCZ.

Methods

One hundred and twenty-four female first-episode patients diagnosed with SCZ according to DSM-IV were recruited. The glucose metabolism parameters, including fasting glucose, insulin, and insulin resistance index were measured. In addition, gonadal hormones, including follicle-stimulating hormone, testosterone, estradiol, progesterone, and luteinizing hormone were also determined in the same group of patients.

Results: Abnormal glucose metabolism and sex hormones were observed in female DNFES patients, with a particularly high rate of insulin resistance (49.6 %). Correlation analysis revealed significant associations between glucose metabolic disturbance and sex hormones (all p < 0.05). Moreover, regression analysis adjusted for age, waist circumference, and BMI revealed that estradiol was negatively correlated with fasting insulin in female patients (β = −0.37, t = −4.0, p < 0.001).

Conclusion

These results provide evidence supporting the presence of disturbance in glucose metabolism and gonadal hormones at the onset of SCZ in female patients, suggesting that these dysregulations interact with each other to be involved in the disease's pathophysiological process.

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女性首发精神分裂症患者糖代谢与性激素的相互关系

精神分裂症（SCZ）是一种复杂的精神障碍，通常出现在青春期晚期或成年早期。SCZ的潜在分子机制尚不清楚。越来越多的证据支持代谢和内分泌系统异常参与SCZ的病理生理。我们的研究旨在探讨SCZ患者的性腺激素与糖代谢的相互关系。方法选取124例根据DSM-IV诊断为SCZ的首发女性患者。测定葡萄糖代谢参数，包括空腹血糖、胰岛素、胰岛素抵抗指数。此外，还测定了同组患者的性激素水平，包括促卵泡激素、睾酮、雌二醇、孕酮、黄体生成素。结果：女性DNFES患者糖代谢和性激素异常，胰岛素抵抗率特别高（49.6%）。相关分析显示糖代谢紊乱与性激素之间存在显著相关性(p <；0.05)。此外，校正了年龄、腰围和BMI的回归分析显示，雌二醇与女性患者的空腹胰岛素呈负相关(β = - 0.37, t = - 4.0, p <；0.001)。结论女性SCZ患者发病时存在糖代谢和性腺激素紊乱，这些紊乱相互作用，参与了SCZ的病理生理过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.