Monte Carlo-based estimation of patient absorbed dose in 99mTc-DMSA, -MAG3, and -DTPA SPECT imaging using the University of Florida (UF) phantoms

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-03-06 DOI:10.1016/j.apradiso.2025.111772

Zeynab Khoshyari , Reza Jahangir , Hashem Miri-Hakimabad , Najmeh Mohammadi , Hossein Arabi

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Abstract

It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the ^99mTc-MAG3, ^99mTc-DTPA, and ^99mTc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old. The results showed that the highest absorbed dose was by kidneys and when ^99mTc-DMSA was used. Also, the highest and lowest absorbed dose in the organs occurred when ^99mTc-DMSA and ^99mTc-MAG3 were used, respectively. The simulation results were in good agreement with the ICRP 128 data.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.