Dietary kelp meal alleviates feed starch intolerance of hybrid snakehead (Channa maculata ♀ × Channa argus ♂) by improving liver glycolipid metabolism and metabolite profile

IF 3.2 2区农林科学 Q1 FISHERIES

Aquaculture Reports Pub Date : 2025-03-11 DOI:10.1016/j.aqrep.2025.102741

Shaodan Wang , Di Sun , Chong Wang , Guohuan Xu , Jixing Zou

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引用次数: 0

Abstract

This study aimed to assess the influence of kelp meal (KM) on growth performance, hepatic glycogen accumulation, hepatic lipid deposition, as well as liver glucose-lipid metabolism in hybrid snakehead (Channa maculata ♀ × Channa argus ♂). A total of 810 juvenile hybrid snakeheads (11.4 ± 0.15 g) were randomly allocated into three groups (3 replicates per group) and given isontirogenous and isolipidic diets containing different levels of KM (10 %、15 %) for 60 days. The results showed that KM diets can significantly reduce liver glycogen accumulation and postprandial hyperglycemia in hybrid snakehead. This is accomplished by increasing levels of insulin secretion and decreasing glucagon levels, thereby increasing liver gluconeogenesis and inhibiting glycolysis. Additionally, there is a considerable reduction in liver lipid deposition with the KM diets. This is due to the lipid oxidative decomposition is promoted, and the liver lipid synthesis is inhibited. Meanwhile, KM diets enhance the body's lipid transport system. Omics analysis showed that the key to KM diets improving liver glycolipid metabolism of hybrid snakehead lies in regulating amino acid metabolism and lipid metabolism, and affecting changes in key metabolites of lipid metabolism. Among them, Jasmolone glucoside, L-Methionine S-oxide, Asparaginyl-Isoleucine and Didymin are key metabolites of great significance. Therefore, our study shows that 10 % KM diets can improve the glycolipid metabolism in hybrid snakehead liver, reduce lipid deposition, and alleviate hyperglycemia.

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饲粮中添加海带粉可改善杂交黑鱼（Channa maculata♀× Channa argus♂）肝脏糖脂代谢和代谢物谱，从而缓解其饲料淀粉不耐受

本试验旨在研究海带粉（KM）对杂交黑鱼（Channa maculata♀× Channa argus♂）生长性能、肝糖原积累、肝脏脂质沉积及肝糖脂代谢的影响。选取杂交蛇头幼鱼810尾（11.4 ± 0.15 g），随机分为3组（每组3个重复），分别饲喂含不同KM水平（10 %、15 %）的等氮等脂饲料，饲喂60 d。结果表明，KM饲粮可显著降低杂交蛇头肝糖原积累和餐后高血糖。这是通过增加胰岛素分泌水平和降低胰高血糖素水平来实现的，从而增加肝脏糖异生和抑制糖酵解。此外，KM日粮显著减少了肝脏脂质沉积。这是由于脂质氧化分解得到促进，肝脏脂质合成受到抑制。同时，KM饮食增强了机体的脂质转运系统。组学分析表明，KM饲粮改善杂交蛇头肝脏糖脂代谢的关键在于调节氨基酸代谢和脂质代谢，并影响脂质代谢关键代谢物的变化。其中茉莉酮葡萄糖苷、l-甲硫氨酸s -氧化物、天冬酰胺异亮氨酸和双地敏是重要的关键代谢产物。因此，本研究表明，饲粮中添加10 % KM可改善杂交蛇头肝脏糖脂代谢，减少脂肪沉积，缓解高血糖。

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来源期刊

Aquaculture Reports Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

5.90

自引率

8.10%

发文量

469

审稿时长

77 days

期刊介绍： Aquaculture Reports will publish original research papers and reviews documenting outstanding science with a regional context and focus, answering the need for high quality information on novel species, systems and regions in emerging areas of aquaculture research and development, such as integrated multi-trophic aquaculture, urban aquaculture, ornamental, unfed aquaculture, offshore aquaculture and others. Papers having industry research as priority and encompassing product development research or current industry practice are encouraged.