MRI-based cortical gray/white matter contrast in young adults who endorse psychotic experiences or are at genetic risk for psychosis

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-03-07 DOI:10.1016/j.pscychresns.2025.111981

Nasimeh Naseri , Dani Beck , Lia Ferschmann , Eira R. Aksnes , Alexandra Havdahl , Maria Jalbrzikowski , Linn B. Norbom , Christian K. Tamnes

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引用次数: 0

Abstract

Research has reported group-level differences in cortical grey/white matter contrast (GWC) in individuals with psychotic disorders. However, no studies to date have explored GWC in individuals at elevated risk for psychosis. In this study, we examined brain microstructure differences between young adults with psychotic-like experiences or a high genetic risk for psychosis and unaffected individuals. Moreover, we investigated the association between GWC and the number of and experiences of psychosis-like symptoms. The sample was obtained from the Avon Longitudinal Study of Parents and Children (ALSPAC): the psychotic experiences study, consisting of young adults with psychotic-like symptoms (n = 119) and unaffected individuals (n = 117), and the schizophrenia recall-by-genotype study, consisting of individuals with a high genetic risk for psychosis (n = 95) and those with low genetic risk for psychosis (n = 95). Statistical analyses were performed using FSL's Permutation Analysis of Linear Models (PALM), controlling for age and sex. The results showed no statistically significant differences in GWC between any of the groups and no significant associations between GWC and the number and experiences of psychosis-like symptoms. In conclusion, the results indicate there are no differences in GWC in individuals with high, low or no risk for psychosis.

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支持精神病经历或有精神病遗传风险的年轻人的mri皮质灰质/白质对比

研究报告了精神障碍患者皮质灰质/白质对比（GWC）的组水平差异。然而，到目前为止，还没有研究探讨精神病高风险个体的GWC。在这项研究中，我们检查了具有精神病样经历或精神病高遗传风险的年轻人与未受影响的个体之间的大脑微观结构差异。此外，我们调查了GWC与精神病样症状的数量和经历之间的关系。样本来自雅芳父母与儿童纵向研究（ALSPAC）：精神病经历研究，包括有精神病样症状的年轻人（n = 119）和未受影响的个体（n = 117），以及精神分裂症基因型回忆研究，包括精神病高遗传风险个体（n = 95）和精神病低遗传风险个体（n = 95）。采用FSL的线性模型排列分析（PALM）进行统计分析，控制年龄和性别。结果显示，GWC在任何组之间没有统计学上的显著差异，GWC与精神病样症状的数量和经历之间也没有显著关联。综上所述，结果表明高、低、无精神病风险个体的GWC没有差异。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.