Associations of prenatal exposure to fine particulate matter and its constituents with small for gestational age risk: A twin study in China

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-03-10 DOI:10.1016/j.ecoenv.2025.118001

Xinqi Zhong , Yuan Zheng , Wan Peng , Yixiang Huang , Lv Wang , Changshun Xia , Qijiong Zhu , Zhiqing Chen , Yuwei Fan , Yiyu Lai , Tao Liu , Qiliang Cui

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Abstract

This study aimed to examine the impact of PM_2.5 and its constituents on small for gestational age (SGA). We collected records of 8082 twin pairs and their mothers from 21 hospitals across China. Concentrations of PM_2.5 and its constituents were from the Tracking Air Pollution dataset. Generalized linear models were utilized in this observational study to explore the relationship between SGA and PM_2.5. An increase in PM_2.5 by one interquartile range during pregnancy was linked to a 17 % increased SGA risk (OR = 1.17, 95 % CI: 1.05–1.31), with a population attributable fraction of 18.97 % (95 %CI: 5.65 %, 30.93 %). Additionally, higher risk of SGA was associated with exposure to ammonium (OR=1.17, 95 %CI: 1.03–1.34), sulfate (OR=1.10, 95 %CI: 1.01–1.21), nitrate (OR=1.16, 95 %CI: 1.02–1.33), black carbon (OR=1.09, 95 %CI: 1.00–1.19), and organic matter (OR=1.11, 95 %CI: 1.00–1.23) during pregnancy. Similar associations were observed for SGA with PM_2.5 and its constituents in late pregnancy (all P < 0.05). Furthermore, individuals conceived via assisted reproduction (OR = 1.22, 95 % CI: 1.03–1.43), with pregnancy complications (OR = 1.23, 95 % CI: 1.07–1.41), and residing in colder areas (OR = 1.20, 95 % CI: 1.02–1.40) shown more susceptible to PM_2.5. Our findings provide evidence that maternal PM_2.5 exposure increased SGA risk, especially during the late pregnancy.

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产前暴露于细颗粒物及其成分与小胎龄风险的关系：中国的一项双胞胎研究

本研究旨在研究PM2.5及其成分对胎龄小（SGA）的影响。我们收集了来自中国21家医院的8082对双胞胎及其母亲的记录。PM2.5及其成分的浓度来自追踪空气污染数据集。本观测研究采用广义线性模型探讨了SGA与PM2.5的关系。怀孕期间PM2.5增加1个四分位数范围与SGA风险增加17. %相关（OR = 1.17, 95 %CI: 1.05-1.31），人群归因分数为18.97 %（95 %CI: 5.65 %,30.93 %）。此外，SGA的高风险与怀孕期间暴露于铵（OR=1.17, 95 %CI: 1.03-1.34）、硫酸盐（OR=1.10, 95 %CI: 1.01-1.21）、硝酸盐（OR=1.16, 95 %CI: 1.02-1.33）、黑碳（OR=1.09, 95 %CI: 1.00-1.19）和有机物（OR=1.11, 95 %CI: 1.00-1.23）有关。妊娠后期SGA与PM2.5及其成分也存在类似的关联（P均为 <； 0.05）。此外，通过辅助生殖受孕的个体（OR = 1.22, 95 % CI: 1.03-1.43），有妊娠并发症的个体（OR = 1.23, 95 % CI: 1.07-1.41），居住在寒冷地区的个体（OR = 1.20, 95 % CI: 1.02-1.40）更容易受到PM2.5的影响。我们的研究结果提供了证据，证明母亲暴露在PM2.5中会增加SGA的风险，尤其是在怀孕后期。

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.