Advances in magnesium-based bioresorbable cardiovascular stents: Surface engineering and clinical prospects

IF 15.8 1区材料科学 Q1 METALLURGY & METALLURGICAL ENGINEERING

Journal of Magnesium and Alloys Pub Date : 2025-03-01 DOI:10.1016/j.jma.2025.01.025

Ganesh Kumar , Subham Preetam , Arunima Pandey , Nick Birbilis , Saad Al-Saadi , Pooria Pasbakhsh , Mikhail Zheludkevich , Poovarasi Balan

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Abstract

Magnesium (Mg)-based bioresorbable stents represent a potentially groundbreaking advancement in cardiovascular therapy; offering temporary vessel support and complete biodegradability—addressing limitations of traditional stents like in-stent restenosis and long-term complications. However, challenges such as rapid corrosion and suboptimal endothelialisation have hindered their clinical adoption. This review highlights the latest breakthroughs in surface modification, alloying, and coating strategies to enhance the mechanical integrity, corrosion resistance, and biocompatibility of Mg-based stents. Key surface engineering techniques, including polymer and bioactive coatings, are examined for their role in promoting endothelial healing and minimising inflammatory responses. Future directions are proposed, focusing on personalised stent designs to optimize efficacy and long-term outcomes, positioning Mg-based stents as a transformative solution in interventional cardiology.

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镁基生物可吸收心血管支架的研究进展：表面工程与临床前景

基于镁（Mg）的生物可吸收支架代表了心血管治疗的潜在突破性进展；提供临时的血管支持和完全的生物降解性，解决了传统支架的局限性，如支架内再狭窄和长期并发症。然而，诸如快速腐蚀和次优内皮化等挑战阻碍了它们的临床应用。本文综述了镁基支架在表面改性、合金化和涂层策略方面的最新突破，以提高镁基支架的机械完整性、耐腐蚀性和生物相容性。关键的表面工程技术，包括聚合物和生物活性涂层，研究了它们在促进内皮愈合和减少炎症反应中的作用。未来的发展方向是专注于个性化支架设计，以优化疗效和长期结果，将mg基支架定位为介入性心脏病学的变革性解决方案。

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来源期刊

Journal of Magnesium and Alloys Engineering-Mechanics of Materials

CiteScore

20.20

自引率

14.80%

发文量

审稿时长

59 days

期刊介绍： The Journal of Magnesium and Alloys serves as a global platform for both theoretical and experimental studies in magnesium science and engineering. It welcomes submissions investigating various scientific and engineering factors impacting the metallurgy, processing, microstructure, properties, and applications of magnesium and alloys. The journal covers all aspects of magnesium and alloy research, including raw materials, alloy casting, extrusion and deformation, corrosion and surface treatment, joining and machining, simulation and modeling, microstructure evolution and mechanical properties, new alloy development, magnesium-based composites, bio-materials and energy materials, applications, and recycling.