NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection

Abstract

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A recent study by Gasteiger and colleagues¹ described a population of circulating natural killer (NK) cells that are recruited and retained in the skin for several weeks following local viral (vaccinia virus) and bacterial (Staphylococcus aureus) infections. These cells, which the authors refer to as tissue resident (tr)NK cells, exhibit increased production of effector molecules (interferon [IFN]-γ, granzyme B [Gzmb], perforin [Prf1]) upon re-challenge, suggesting a role in enhanced pathogen

Acknowledgments

The work was supported by funding from the National Health and Medical Research Council of Australia (NHMRC 2004397, 1119298, and 2026377).

Declaration of interests

The authors declare no competing interests.