Stored mRNA enables rapid cytokine production in tissue-resident memory T cells

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-03-11 DOI:10.1038/s41590-025-02111-z

引用次数: 0

Abstract

Using single-cell RNA sequencing and mRNA translation analysis, we identified CD4+ tissue-resident memory T cells as a primary T cell subset that stores cytokine mRNA that can subsequently be translated upon T cell activation to rapidly produce cytokine proteins.

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储存的mRNA使组织驻留记忆T细胞快速产生细胞因子

通过单细胞 RNA 测序和 mRNA 翻译分析，我们发现 CD4+ 组织驻留记忆 T 细胞是一种储存细胞因子 mRNA 的初级 T 细胞亚群，这些细胞因子 mRNA 可在 T 细胞活化后被翻译，从而快速产生细胞因子蛋白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.