Multimodal imaging for evaluation and quantification of atrophy progression in extensive macular atrophy with pseudodrusen

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-03-05 DOI:10.1016/j.pdpdt.2025.104550

Rukiye Aydin, Merve Ozbek, Ozgur Artunay

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引用次数: 0

Abstract

Aim

To present the atrophy progression rate with fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings in patients with extensive macular atrophy with a pseudodrusen-like appearance.

Methods

Eight patients who were followed up with the diagnosis of diffuse macular atrophy accompanied by pseudodrusen were included. Medical records, FAF, and OCT images at consecutive follow-ups were reviewed. Measurement of the atrophic area was performed on FAF images using the Heidelberg RegionFinder software at baseline and each annual visit until the last available follow-up.

Results

The mean age was 56.75 ± 5.92 years (range, 45–65 years). Nyctalopia was observed in all patients. Macular atrophy of various sizes with a larger vertical diameter was present. Diffuse pseudodrusen-like deposits extending to the mid-peripheral retina were identified. The mean follow-up period was 38.33 ± 14.60 months (range, 26–60 months). The mean area of atrophy at baseline was 13.05 ± 7.93 mm² and reached 15.31 ± 7.93 mm² at the first-year follow-up (p < 0.001). At the end of the follow-up period, the mean area of atrophy was 17.32 ± 7.90 mm² (p = 0.001). The yearly rate of atrophy expansion was 2.13 mm²/year. The mean subfoveal choroidal thickness at baseline decreased markedly during the follow-up period (p = 0.000).

Conclusions

The progression rate of macular atrophy in these patients is faster than the geographic atrophy associated with age-related macular degeneration. In this era of therapeutic options, it has become more important to assess atrophy progression. Distinguishing different macular atrophy forms may be crucial for selecting suitable candidates for future interventional treatments.

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多模态成像用于评估和量化假性黄斑萎缩的萎缩进展。

目的：通过眼底自身荧光（FAF）和光学相干断层扫描（OCT）观察假性黄斑样广泛黄斑萎缩患者的萎缩进展率。方法：对8例诊断为弥漫性黄斑萎缩伴假性黄斑变性的患者进行随访。回顾了连续随访的医疗记录、FAF和OCT图像。在基线和每年的随访中使用海德堡RegionFinder软件对自身荧光图像进行萎缩面积测量，直到最后一次可用的随访。结果：平均年龄56.75±5.92岁（45 ~ 65岁）。所有患者均有夜盲症。黄斑萎缩大小不一，纵径较大。弥漫性假性样沉积物延伸至视网膜中周。平均随访时间为38.33±14.60个月（范围26 ~ 60个月）。基线时平均萎缩面积为13.05±7.93 mm2，第一年随访时萎缩面积为15.31±7.93 mm2 （p=0.001）。年萎缩扩张率为2.13 mm2/年。在随访期间，基线时平均中央凹下脉络膜厚度明显下降（p=0.000）。结论：这些患者黄斑萎缩的进展速度快于与年龄相关的黄斑变性相关的地域性萎缩。在这个治疗选择的时代，评估萎缩的进展变得更加重要。区分不同的黄斑萎缩形式可能对选择合适的候选人进行未来的介入治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.