Establishing a Newborn Screening Programme: A Success Story from a Low-Resource Setting.

Hafsa Majid, Lena Jafri, Sibtain Ahmed, Khadija Nuzhat Humayun, Salman Kirmani, Aysha Habib Khan
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Abstract

The purpose of this communication was to assess the clinical effectiveness of a newborn screening (NBS) programme for congenital hypothyroidism (CH) in a tertiary care centre. This cross-sectional study was conducted from January 2019 to December 2023. Thyroid-stimulating hormone (TSH) on dried blood spot (DBS) specimens collected after 24 hours of birth with >10 mIU/L was further confirmed by testing serum TSH and FT4, and CH cases were referred to a paediatric endocrinologist for management. During the study period, coverage of NBS was tracked. Over a four-year period, 30,402 newborns were screened, with 96.2% coverage (total births-31610). Positive screening results (TSH>10 mIU/L) were found in 1.9% of neonates (n = 586), with confirmatory tests performed in 63.13% (n = 370) of these cases. CH was confirmed in 27 cases, with an incidence of 1:1126. This study demonstrated that NBS for CH was successfully implemented and highly effective. However, there is a need to further improve recall rates. Key Words: Congenital hypothyroidism, Dried blood spot testing, Newborn screening, Clinical efficacy.

建立新生儿筛查计划:低资源环境下的成功案例。
本交流的目的是评估三级保健中心先天性甲状腺功能减退症(CH)新生儿筛查(NBS) 计划 的临床效果。这项横断面研究于2019年1月至2023年12月进行。出生24小时后采集血干斑(DBS)标本,bbb10 mIU/L,通过检测血清促甲状腺激素(TSH)和FT4进一步确认,CH病例转至 儿科内分泌科治疗。在研究期间,跟踪了国家统计局的覆盖率。在四年期间,对30,402名新生儿进行了筛查,覆盖率为96.2%(出生总数为31610)。筛查结果阳性的新生儿(n = 586)为1.9%,其中确诊试验为63.13% (n = 370)。27例确诊为CH,发病率为1:11 126。本研究表明,NBS对CH的实施是成功的和高效的。然而,有必要进一步提高召回率。关键词:先天性甲状腺功能减退症,干血斑点试验,新生儿筛查,临床疗效
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