Comparison of Structural Changes after Epiretinal Membrane Peeling between Nonglaucomatous Eyes and Eyes with Open-Angle Glaucoma.

Q2 Medicine

Ophthalmology. Glaucoma Pub Date : 2025-03-07 DOI:10.1016/j.ogla.2025.03.001

Dong Kyun Han, Eun Ji Lee, Tae-Woo Kim

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引用次数: 0

Abstract

Purpose: To compare the structural changes in the peripapillary and macular regions following pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling between nonglaucomatous eyes and eyes with primary open-angle glaucoma (POAG).

Design: A retrospective, longitudinal, observational study.

Participants: Sixty-eight eyes (34 POAG and 34 nonglaucomatous eyes) that underwent PPV with ERM peeling surgery.

Methods: This retrospective study analyzed 68 eyes (34 POAG and 34 nonglaucomatous eyes) that underwent PPV with ERM peeling surgery. The circumpapillary retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and interdigitation zone (IZ) defects were assessed using spectral-domain OCT before and 6 months after surgery and compared between nonglaucomatous and POAG eyes.

Main outcome measures: Comparison of structural changes between POAG eyes and nonglaucomatous eyes after PPV with ERM peeling surgery.

Results: Both nonglaucomatous and POAG eyes showed significant reductions in CMT and temporal RNFL thicknesses postoperatively, but significant increases were observed in nasal RNFL thicknesses. However, the changes were less prominent in POAG eyes, with significantly smaller decreases in CMT (P = 0.044) and temporal RNFL thickness (P = 0.020), and smaller increases in the nasal (P = 0.022) and inferonasal (P = 0.005) RNFL thicknesses. In nonglaucomatous eyes, the length of the IZ defect decreased significantly postoperatively (P = 0.009), while no significant change was observed in POAG eyes (P = 0.115).

Conclusions: Structural changes in the macula and peripapillary areas following PPV with ERM peeling were less pronounced in POAG eyes than in nonglaucomatous eyes, probably due to preexisting optic nerve damage. These different structural outcomes should be considered in the diagnosis and monitoring of patients with glaucoma accompanied by ERM.

Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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非青光眼与开角型青光眼视网膜外膜剥离后结构变化的比较。

目的：比较非青光眼和原发性开角型青光眼（POAG）视网膜前膜（ERM）剥离的玻璃体切除（PPV）术后乳头周围和黄斑区域的结构变化。设计：回顾性、纵向、观察性研究。参与者：68只眼（34只POAG和34只非青光眼）行PPV合并ERM剥离手术。方法：本回顾性研究分析了68只眼（34只POAG和34只非青光眼）行PPV合并ERM剥离手术。采用光谱域光学相干断层成像技术评估术前和术后6个月视网膜乳头周围神经纤维层（RNFL）厚度、中央黄斑厚度（CMT）和指间带（IZ）缺损，并比较非青光眼和POAG眼的差异。结果：非青光眼和POAG眼术后CMT和颞部RNFL厚度均显著降低，但鼻RNFL厚度显著增加。然而，POAG眼的变化不太明显，CMT （P=0.044）和颞部RNFL厚度（P=0.020）的下降幅度较小，鼻（P=0.022）和鼻间（P=0.005） RNFL厚度的增加幅度较小。非青光眼术后IZ缺损长度明显缩短（P=0.009），而POAG眼术后缺损长度无明显变化（P=0.115）。结论：与非青光眼相比，POAG眼在PPV合并ERM剥落后黄斑和乳头周围区域的结构变化不明显，这可能是由于先前存在的视神经损伤。在诊断和监测伴有ERM的青光眼患者时，应考虑这些不同的结构结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology. Glaucoma Medicine-Medicine (all)

CiteScore

4.20

自引率

0.00%

发文量

140