Influence of COVID-19 Vaccination on Treatment-Related Adverse Events and Oncologic Outcomes of Nonmetastatic Nasopharyngeal Carcinoma

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-03-10 DOI:10.1002/hed.28130

Minglong Liu, Bin Zhang, Yufei Pan, Xiaoping Lin, Guanhong Luo, Yuan Xie, Xiaolan Ruan, Yu Pan, Yi Liang, Defeng Wang, Yuejia Wei, Hengwei Chen, Guorong Tang, Wei Jiang

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引用次数: 0

Abstract

Background

The influence of COVID-19 vaccination before chemoradiotherapy on nonmetastatic nasopharyngeal carcinoma (NPC) is not known.

Methods

Propensity score matching was used to minimize potential selection bias between groups. Primary endpoints were treatment-related adverse events (TRAEs). The Kaplan–Meier method and Cox proportional hazards models were performed to conduct survival analysis. The Benjamini–Hochberg false discovery rate control procedure was used to adjust for multiple comparisons.

Results

Eight hundred ninety-three patients with newly diagnosed nonmetastatic NPC were enrolled. On propensity score matching analysis, vaccinated group exhibited higher prevalence of neutropenia (p = 0.049), fatigue (p = 0.011) during induction chemotherapy, and higher prevalence of fatigue (p =0.016) during radiotherapy after adjustment for multiple comparisons. [Correction added after first online publication on 20 March 2025. P values have been updated in this sentence.] No significant differences were observed in 2-year OS, PFS, DMFS, and LRRFS in matched groups. Additionally, vaccinated patients exhibited a high and comparable absolute lymphocyte count.

Conclusions

COVID-19 vaccination before chemoradiotherapy increases the prevalence of acute TRAEs, while no significant influence is observed on the oncologic outcomes of patients with nonmetastatic NPC.

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COVID-19疫苗接种对非转移性鼻咽癌治疗相关不良事件和肿瘤预后的影响

背景：放化疗前接种COVID-19疫苗对非转移性鼻咽癌（NPC）的影响尚不清楚。方法：采用倾向评分匹配，尽量减少组间潜在的选择偏倚。主要终点是治疗相关不良事件（TRAEs）。采用Kaplan-Meier法和Cox比例风险模型进行生存分析。采用Benjamini-Hochberg错误发现率控制程序对多重比较进行调整。结果：893例新诊断的非转移性鼻咽癌患者入组。在倾向评分匹配分析中，经多重比较调整后，接种疫苗组在诱导化疗期间中性粒细胞减少（p = 0.045）和疲劳（p = 0.010）的患病率较高，在放疗期间疲劳的患病率较高（p = 0.015）。配对组2年OS、PFS、DMFS和LRRFS均无显著差异。此外，接种疫苗的患者表现出较高的绝对淋巴细胞计数。结论：放化疗前接种COVID-19疫苗可增加急性trae的发生率，但对非转移性鼻咽癌患者的肿瘤预后无显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.