FIB-4 Index Can Predict Mortality in Hospitalized Patients with COVID-19 Infection, Independent of CT Severity Score.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Archives of Iranian Medicine Pub Date : 2025-02-01 DOI:10.34172/aim.33514

Faeze Salahshour, Sahar Karimpour Reyhan, Kazem Zendedel, Kiana Seifouri, Monireh Sadat Seyyedsalehi, Parnian Naghavi, Mahsa Abbaszadeh, Alireza Esteghamati, Manouchehr Nakhjavani, Soghra Rabizadeh

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引用次数: 0

Abstract

Background: The fibrosis 4 (FIB-4) index is typically used in assessing liver fibrosis, and has shown potential in predicting the outcome in various diseases. This study aims to evaluate the predictive power of the FIB-4 index for mortality in COVID-19 patients admitted to a reference hospital in Tehran, Iran.

Methods: In this prospective cohort study, 387 patients with COVID-19 without diabetes, were categorized into deceased and surviving groups. We compared anthropometric and demographic data, liver function tests, CT scores, and FIB-4 indices between the groups. Multivariate logistic regression assessed the independent association of FIB-4 with mortality.

Results: Among the 387 patients, (all non-diabetics), 58 (15%) died, with a higher mortality rate observed in patients with a FIB-4 index≥2.6 (63.4%) compared to those with FIB-4<2.6 (29.7%). Deceased patients were considerably older and more likely to be hypertensive (P values<0.001). After adjustment of confounding factors, a FIB-4 index≥2.6 was found to be independently associated with increased mortality (OR: 13.511, 95% CI: 1.356-134.580, P=0.026).

Conclusion: The FIB-4 index, calculable by routine laboratory tests, may be a valuable prognostic factor for COVID-19 mortality. This easily obtainable marker could help identify high-risk patients early, potentially allowing for more rapid intervention and treatment prioritization.

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FIB-4指数可预测COVID-19感染住院患者的死亡率，与CT严重程度评分无关。

背景：纤维化4 （FIB-4）指数通常用于评估肝纤维化，并显示出预测各种疾病预后的潜力。本研究旨在评估FIB-4指数对伊朗德黑兰一家参考医院收治的COVID-19患者死亡率的预测能力。方法：在这项前瞻性队列研究中，将387例无糖尿病的COVID-19患者分为死亡组和生存组。我们比较了两组之间的人体测量学和人口学数据、肝功能检查、CT评分和FIB-4指数。多因素logistic回归评估FIB-4与死亡率的独立关联。结果：387例患者（均为非糖尿病患者）中，58例（15%）死亡，FIB-4指数≥2.6的患者死亡率（63.4%）高于FIB-4P值（=0.026）的患者。结论：可通过常规实验室检查计算的FIB-4指数可能是预测COVID-19死亡率的一个有价值的预后因素。这种容易获得的标记物可以帮助早期识别高危患者，从而有可能更快地进行干预和确定治疗的优先顺序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Iranian Medicine 医学-医学：内科

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Aim and Scope: The Archives of Iranian Medicine (AIM) is a monthly peer-reviewed multidisciplinary medical publication. The journal welcomes contributions particularly relevant to the Middle-East region and publishes biomedical experiences and clinical investigations on prevalent diseases in the region as well as analyses of factors that may modulate the incidence, course, and management of diseases and pertinent medical problems. Manuscripts with didactic orientation and subjects exclusively of local interest will not be considered for publication.The 2016 Impact Factor of "Archives of Iranian Medicine" is 1.20.