Anne Vejen Hansen, Kjell Ej Håkansson, Anders P Mikkelsen, Zarqa Ali, Anja Pinborg, Øjvind Lidegaard, Charlotte Suppli Ulrik
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引用次数: 0
Abstract
Background: Asthma is common among women of reproductive age. Prior studies have revealed an association between asthma and fertility by reporting prolonged time to pregnancy and lower fecundability.
Objective: Investigate fertility in women treated with asthma medication compared to women without asthma.
Methods: All women born from 1976 to 1999, living in Denmark on their 18th birthday, were followed 1994 to 2017. Asthma was defined as repeated fulfilment of asthma medication prescriptions and severity was classified according to the Global Initiative for Asthma guidelines (GINA). Outcome was fertility treatment in women with asthma compared to women without asthma, applying a Cox regression model adjusted for age, calendar year, and education.
Results: The cohort comprised 765,606 women followed-up, starting on their 18th birthday, for a median time of 10.8 years [IQR 5.3-17.5]. Compared to women without asthma, women with asthma had a comparable proportion giving birth during follow-up, slightly more experienced fetal loss (17.0% vs. 15.8 %) and required fertility treatment (5.6% vs. 5.0%). The risk of fertility treatment was significantly higher in women with asthma: HR 1.10 (1.07-1.14). Women on GINA treatment step 4-5 had an even higher risk of fertility treatment HR 1.59 (1.41-1.80) and, likewise, women with ≥ 3 prior exacerbations of asthma, HR 1.36 (1.17-1.58).
Conclusion: Women with asthma have an increased use of fertility treatment, which correlates with asthma severity and exacerbation burden. However, asthma does not seem to affect number of live births.
期刊介绍：
JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases.
This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders.
The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.
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