Allostatic Load and Cardiovascular Disease: A Systematic Review

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Preventive Medicine Pub Date : 2025-03-05 DOI:10.1016/j.amepre.2025.02.016

Elizabeth Evans MS, CCC-SLP , Molly Jacobs PhD , David Fuller PhD , Karen Hegland PhD , Charles Ellis PhD

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引用次数: 0

Abstract

Introduction

Cardiovascular disease is a leading cause of morbidity and mortality. In the past 3 decades, allostatic load—a physiological representation of cumulative life stress—has been associated with increased risk of cardiovascular disease incidence and mortality. Additionally, differences in allostatic load may partially explain persistent disparities in cardiovascular disease outcomes. However, there is notable variation in cardiovascular disease types and subsequent impairments suggesting this association may not be similar across cardiovascular disease types and demographic characteristics.

Methods

This study is a systematic review conducted in 2024 of current knowledge on the relationship between allostatic load and cardiovascular disease. A literature search using the electronic databases PubMed, SCOPUS, and Web of Science and the keywords allostatic load and cardiovascular disease was conducted. A total of 233 articles were identified in initial review and 22 studies were identified for inclusion in this review.

Results

This review found that allostatic load was associated with a composite score of cardiovascular disease incidence but there was less clarity on the relationship with cardiovascular disease mortality and other cardiovascular disease outcomes. Additionally, there was some variation between cardiovascular disease types and the relationship with allostatic load as well as intersectional race and gender differences.

Conclusions

This review revealed notable gaps in the current knowledge of the relationship between cardiovascular disease and allostatic load. Future research is necessary to evaluate how this relationship differs across demographic characteristics, cardiovascular disease types, cardiovascular disease outcomes such as impairment, and disease processes. Future research should also identify standardized measures of allostatic load and determine how the social determinants impact allostatic load across the lifespan.

查看原文本刊更多论文

适应负荷与心血管疾病：系统综述。

简介：心血管疾病（CVD）是发病率和死亡率的主要原因。在过去的30年里，适应负荷——一种累积生活压力的生理表征——与心血管疾病发病率和死亡率的增加有关。此外，适应负荷的差异可能部分解释了心血管疾病结局的持续差异。然而，CVD类型和随后的损伤存在显著差异，表明这种关联可能在CVD类型和人口统计学特征之间不相似。方法：本研究是对2024年关于适应负荷与心血管疾病关系的现有知识进行的系统综述。使用PubMed、SCOPUS和Web of Science电子数据库进行文献检索，检索关键词为“适应负荷”和“心血管疾病”。在最初的综述中确定了233篇文章，在本次综述中确定了22项研究。结果：本综述发现，适应负荷与CVD发病率的综合评分相关，但与CVD死亡率和其他CVD结局的关系不太清楚。此外，CVD类型之间存在一定的差异，与适应负荷的关系以及交叉的种族和性别差异。结论：这篇综述揭示了目前关于心血管疾病和适应负荷之间关系的知识存在显著差距。未来的研究有必要评估这种关系在人口统计学特征、CVD类型、CVD结果（如损伤）和疾病过程中的差异。未来的研究还应该确定适应负荷的标准化措施，并确定社会决定因素如何影响整个生命周期的适应负荷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Preventive Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

8.60

自引率

1.80%

发文量

395

审稿时长

32 days

期刊介绍： The American Journal of Preventive Medicine is the official journal of the American College of Preventive Medicine and the Association for Prevention Teaching and Research. It publishes articles in the areas of prevention research, teaching, practice and policy. Original research is published on interventions aimed at the prevention of chronic and acute disease and the promotion of individual and community health. Of particular emphasis are papers that address the primary and secondary prevention of important clinical, behavioral and public health issues such as injury and violence, infectious disease, women''s health, smoking, sedentary behaviors and physical activity, nutrition, diabetes, obesity, and substance use disorders. Papers also address educational initiatives aimed at improving the ability of health professionals to provide effective clinical prevention and public health services. Papers on health services research pertinent to prevention and public health are also published. The journal also publishes official policy statements from the two co-sponsoring organizations, review articles, media reviews, and editorials. Finally, the journal periodically publishes supplements and special theme issues devoted to areas of current interest to the prevention community.