Role of FDG PET/CT in bacteremia and fever of unknown origin: a pictorial overview of finding the culprit.

IF 1.5 4区医学

the Quarterly Journal of Nuclear Medicine and Molecular Imaging Pub Date : 2025-03-01 DOI:10.23736/S1824-4785.25.03618-0

Ayah A Nawwar, Soren Hess, Lucia Leccisotti, Francois Jamar, Edel Noriega-Alvarez, Domenico Albano, Olivier Gheysens

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Abstract

¹⁸F fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) has established itself as a critical diagnostic tool in the evaluation of patients with bacteremia and fever of unknown origin (FUO), particularly following futile conventional investigations. These conditions are often challenging due to diverse underlying etiologies, including infections, inflammatory conditions and malignancies. PET/CT has the advantage of being a whole-body imaging technique with high sensitivity for detecting areas of increased metabolism often associated with infection or inflammation. In bacteremia, [¹⁸F]FDG PET/CT can help identify metastatic infections, endocarditis, or abscesses which may be clinically silent and missed on conventional imaging. In FUO, it helps to identify underlying etiologies, directing treatment and management strategies. This review aims to describe the role of PET/CT imaging in these diverse clinical scenarios. Perspectives in the field, including novel equipment and tracers, will be briefly discussed.

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FDG PET/CT在菌血症和不明原因发热中的作用：寻找罪魁祸首的图像概述。

18F氟脱氧葡萄糖（[18F]FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）已成为评估菌血症和不明原因发热（FUO）患者的关键诊断工具，特别是在无效的常规调查之后。由于各种潜在病因，包括感染、炎症和恶性肿瘤，这些疾病往往具有挑战性。PET/CT的优点是作为一种全身成像技术，具有高灵敏度，可检测代谢增加的区域，通常与感染或炎症有关。在菌血症中[18F]， FDG PET/CT可以帮助识别转移性感染、心内膜炎或脓肿，这些感染在临床上可能是沉默的，在常规影像学上可能被遗漏。在FUO中，它有助于确定潜在的病因，指导治疗和管理策略。这篇综述旨在描述PET/CT成像在这些不同的临床情况中的作用。在该领域的观点，包括新的设备和示踪剂，将简要讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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the Quarterly Journal of Nuclear Medicine and Molecular Imaging Medicine-Radiology, Nuclear Medicine and Imaging

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期刊介绍： The Quarterly Journal of Nuclear Medicine and Molecular Imaging publishes scientific papers on clinical and experimental topics of nuclear medicine. Manuscripts may be submitted in the form of editorials, original articles, review articles and special articles. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.