[Ghosts of the virus : unmasking the persistent threat of SARS-CoV-2 in Long COVID].

IF 0.7 4区 医学 Q4 VIROLOGY
Virologie Pub Date : 2025-02-01 DOI:10.1684/vir.2025.1073
Mariangela Cavarelli
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引用次数: 0

Abstract

Long COVID has emerged as a debilitating condition, severely impacting the daily functioning and quality of life of affected individuals. The pathogenesis of Long COVID is complex and multifactorial, involving immune dysregulation, persistent inflammation, and potential reactivation of other pathogens. A key driver of Long COVID is the potential persistence of SARS-CoV-2 in various tissues beyond the respiratory tract, leading to the formation of viral reservoirs that contribute to ongoing symptoms, several months after initial infection. These reservoirs have been suggested in the gastrointestinal tract, central nervous system, cardiovascular system, and other tissues, often persisting months after the initial infection. Additionally, viral RNA and proteins in these tissues are associated with chronic inflammation and immune system disruptions, which are primary contributors to Long COVID symptoms. This article explores the mechanisms and consequences of SARS-CoV-2 persistence in respiratory and non-respiratory tissues, highlighting its impact on the immune system and underscoring critical areas for future research to improve outcomes for individuals suffering from Long COVID.

[病毒的幽灵:揭露SARS-CoV-2在长COVID中的持续威胁]。
新冠肺炎已成为一种使人衰弱的疾病,严重影响患者的日常功能和生活质量。长冠肺炎的发病机制复杂且多因素,涉及免疫失调、持续炎症和其他病原体的潜在再激活。长COVID的一个关键驱动因素是SARS-CoV-2可能在呼吸道以外的各种组织中持续存在,导致病毒库的形成,在初次感染后几个月导致持续的症状。这些宿主存在于胃肠道、中枢神经系统、心血管系统和其他组织中,通常在初次感染后持续数月。此外,这些组织中的病毒RNA和蛋白质与慢性炎症和免疫系统破坏有关,这是长期COVID症状的主要原因。本文探讨了SARS-CoV-2在呼吸和非呼吸组织中持续存在的机制和后果,强调了其对免疫系统的影响,并强调了未来研究的关键领域,以改善长期COVID患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virologie
Virologie VIROLOGY-
CiteScore
1.20
自引率
22.20%
发文量
31
审稿时长
>12 weeks
期刊介绍: Virologie offers top-level information for all those for whom virology is already the main or an important part of their activity: biologists, clinicians, pharmacists, veterinarians, agronomists, etc.
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